USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

Autophagy is implicated in self-renewal of stem cells, including embryonic stem cells (ES cells). Here the authors demonstrate EPG5 is highly expressed in ES cells, and its deubiquitylation by USP8 stimulates its interaction with LC3 to promote autophagy and maintenance of stemness.

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Autores principales:	Haifeng Gu, Xingxing Shi, Chao Liu, Chaoqun Wang, Ning Sui, Yu Zhao, Jiaqi Gong, Fuping Wang, Hong Zhang, Wei Li, Tongbiao Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c74f5c2d2f504fb9a202f4f7c7b79dfe
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spelling	oai:doaj.org-article:c74f5c2d2f504fb9a202f4f7c7b79dfe2021-12-02T16:57:52ZUSP8 maintains embryonic stem cell stemness via deubiquitination of EPG510.1038/s41467-019-09430-42041-1723https://doaj.org/article/c74f5c2d2f504fb9a202f4f7c7b79dfe2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09430-4https://doaj.org/toc/2041-1723Autophagy is implicated in self-renewal of stem cells, including embryonic stem cells (ES cells). Here the authors demonstrate EPG5 is highly expressed in ES cells, and its deubiquitylation by USP8 stimulates its interaction with LC3 to promote autophagy and maintenance of stemness.Haifeng GuXingxing ShiChao LiuChaoqun WangNing SuiYu ZhaoJiaqi GongFuping WangHong ZhangWei LiTongbiao ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haifeng Gu Xingxing Shi Chao Liu Chaoqun Wang Ning Sui Yu Zhao Jiaqi Gong Fuping Wang Hong Zhang Wei Li Tongbiao Zhao USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
description	Autophagy is implicated in self-renewal of stem cells, including embryonic stem cells (ES cells). Here the authors demonstrate EPG5 is highly expressed in ES cells, and its deubiquitylation by USP8 stimulates its interaction with LC3 to promote autophagy and maintenance of stemness.
format	article
author	Haifeng Gu Xingxing Shi Chao Liu Chaoqun Wang Ning Sui Yu Zhao Jiaqi Gong Fuping Wang Hong Zhang Wei Li Tongbiao Zhao
author_facet	Haifeng Gu Xingxing Shi Chao Liu Chaoqun Wang Ning Sui Yu Zhao Jiaqi Gong Fuping Wang Hong Zhang Wei Li Tongbiao Zhao
author_sort	Haifeng Gu
title	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
title_short	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
title_full	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
title_fullStr	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
title_full_unstemmed	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
title_sort	usp8 maintains embryonic stem cell stemness via deubiquitination of epg5
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c74f5c2d2f504fb9a202f4f7c7b79dfe
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USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

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