The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis

The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis

Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardiomyocyte function due to inactivation of the DNA d...

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Autores principales: Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Junco S. Warren, Zhe Tian, Shunshun Zhu, Haruki Horiguchi, Aman Makaju, Anna Bakhtina, Jun Morinaga, Taichi Sugizaki, Kaname Hirashima, Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, Yoshihiro Komohara, Tomohiko Wakayama, Shinichi Nakagawa, Sarah Franklin, Koichi Node, Kimi Araki, Yuichi Oike
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c
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spelling oai:doaj.org-article:c7569bc158f84c42902d65025ac3c85c2021-12-02T16:49:11ZThe lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis10.1038/s41467-021-22735-72041-1723https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22735-7https://doaj.org/toc/2041-1723Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardiomyocyte function due to inactivation of the DNA damage response and activation of mitochondrial bioenergetics.Michio SatoTsuyoshi KadomatsuKeishi MiyataJunco S. WarrenZhe TianShunshun ZhuHaruki HoriguchiAman MakajuAnna BakhtinaJun MorinagaTaichi SugizakiKaname HirashimaKumiko YoshinobuMai ImasakaMasatake ArakiYoshihiro KomoharaTomohiko WakayamaShinichi NakagawaSarah FranklinKoichi NodeKimi ArakiYuichi OikeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michio Sato
Tsuyoshi Kadomatsu
Keishi Miyata
Junco S. Warren
Zhe Tian
Shunshun Zhu
Haruki Horiguchi
Aman Makaju
Anna Bakhtina
Jun Morinaga
Taichi Sugizaki
Kaname Hirashima
Kumiko Yoshinobu
Mai Imasaka
Masatake Araki
Yoshihiro Komohara
Tomohiko Wakayama
Shinichi Nakagawa
Sarah Franklin
Koichi Node
Kimi Araki
Yuichi Oike
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
description Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardiomyocyte function due to inactivation of the DNA damage response and activation of mitochondrial bioenergetics.
format article
author Michio Sato
Tsuyoshi Kadomatsu
Keishi Miyata
Junco S. Warren
Zhe Tian
Shunshun Zhu
Haruki Horiguchi
Aman Makaju
Anna Bakhtina
Jun Morinaga
Taichi Sugizaki
Kaname Hirashima
Kumiko Yoshinobu
Mai Imasaka
Masatake Araki
Yoshihiro Komohara
Tomohiko Wakayama
Shinichi Nakagawa
Sarah Franklin
Koichi Node
Kimi Araki
Yuichi Oike
author_facet Michio Sato
Tsuyoshi Kadomatsu
Keishi Miyata
Junco S. Warren
Zhe Tian
Shunshun Zhu
Haruki Horiguchi
Aman Makaju
Anna Bakhtina
Jun Morinaga
Taichi Sugizaki
Kaname Hirashima
Kumiko Yoshinobu
Mai Imasaka
Masatake Araki
Yoshihiro Komohara
Tomohiko Wakayama
Shinichi Nakagawa
Sarah Franklin
Koichi Node
Kimi Araki
Yuichi Oike
author_sort Michio Sato
title The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
title_short The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
title_full The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
title_fullStr The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
title_full_unstemmed The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
title_sort lncrna caren antagonizes heart failure by inactivating dna damage response and activating mitochondrial biogenesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c
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