Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease.
<h4>Background</h4>The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD).<h4>Methods<...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c758ffafab40495485ed7f50c01f896b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c758ffafab40495485ed7f50c01f896b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c758ffafab40495485ed7f50c01f896b2021-11-25T06:19:18ZAssociation between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease.1932-620310.1371/journal.pone.0251333https://doaj.org/article/c758ffafab40495485ed7f50c01f896b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251333https://doaj.org/toc/1932-6203<h4>Background</h4>The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD).<h4>Methods</h4>A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses.<h4>Results</h4>In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 1.31-1.50, P < 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53-2.43, P < 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively.<h4>Conclusion</h4>The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD.Il Young KimByung Min YeMin Jeong KimSeo Rin KimDong Won LeeHyo Jin KimHarin RheeSang Heon SongEun Young SeongSoo Bong LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251333 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Il Young Kim Byung Min Ye Min Jeong Kim Seo Rin Kim Dong Won Lee Hyo Jin Kim Harin Rhee Sang Heon Song Eun Young Seong Soo Bong Lee Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| description |
<h4>Background</h4>The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD).<h4>Methods</h4>A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses.<h4>Results</h4>In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 1.31-1.50, P < 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53-2.43, P < 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively.<h4>Conclusion</h4>The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD. |
| format |
article |
| author |
Il Young Kim Byung Min Ye Min Jeong Kim Seo Rin Kim Dong Won Lee Hyo Jin Kim Harin Rhee Sang Heon Song Eun Young Seong Soo Bong Lee |
| author_facet |
Il Young Kim Byung Min Ye Min Jeong Kim Seo Rin Kim Dong Won Lee Hyo Jin Kim Harin Rhee Sang Heon Song Eun Young Seong Soo Bong Lee |
| author_sort |
Il Young Kim |
| title |
Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| title_short |
Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| title_full |
Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| title_fullStr |
Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| title_full_unstemmed |
Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| title_sort |
association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/c758ffafab40495485ed7f50c01f896b |
| work_keys_str_mv |
AT ilyoungkim associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT byungminye associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT minjeongkim associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT seorinkim associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT dongwonlee associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT hyojinkim associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT harinrhee associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT sangheonsong associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT eunyoungseong associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease AT soobonglee associationbetweenserumuricacidandleftventricularhypertrophyleftventriculardiastolicdysfunctioninpatientswithchronickidneydisease |
| _version_ |
1718413891615064064 |