Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

Pengtao Sun,1,* Chunzhi Fan,2,* Rengui Wang,1 Tongwei Chu,3 Xiaoli Sun,1 Dongxue Zhang,4 Xuechao Du5 1Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 2Department of Ultrasound Medicine, Beijing Chaoyang Hospital,...

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Autores principales:	Sun P, Fan C, Wang R, Chu T, Sun X, Zhang D, Du X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	atherosclerosis computed tomography diabetes mellitus pancreatic steatosis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c75b7115f570491fbefe61500454b4ac
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spelling	oai:doaj.org-article:c75b7115f570491fbefe61500454b4ac2021-12-02T11:41:55ZComputed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China1178-7007https://doaj.org/article/c75b7115f570491fbefe61500454b4ac2021-03-01T00:00:00Zhttps://www.dovepress.com/computed-tomography-estimated-pancreatic-steatosis-is-associated-with--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Pengtao Sun,1,* Chunzhi Fan,2,* Rengui Wang,1 Tongwei Chu,3 Xiaoli Sun,1 Dongxue Zhang,4 Xuechao Du5 1Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 2Department of Ultrasound Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 3Department of Ultrasound, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 4Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 5Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuechao DuDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, 5 Jingyuan Road, Shijingshan District, Beijing, 100043, People’s Republic of ChinaTel +86 13552588221Email duxuechao@ccmu.edu.cnObjective: To explore potential effects of pancreatic fat content measured by computed  tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Methods: T2DM patients who underwent an un-enhanced CT scan of the upper abdomen and ultrasound of the carotid artery were enrolled. The patients were divided into a non-plaque group and a plaque group (including hypoechoic plaque subgroup and non-hypoechoic plaque subgroup). The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and the difference between pancreatic and splenic attenuation (P-S) were calculated. The cutoff values of P/S and P-S were obtained using receiver operating characteristic curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque.Results: 337 patients were enrolled, including 101 cases in the non-plaque group, 146 cases in the hypoechoic plaque subgroup, and 90 cases in the non-hypoechoic plaque subgroup. P/S and P-S in hypoechoic plaque group were lower than those in non-plaque group, with a cutoff value of P/S and P-S as 0.72 and − 13.33, respectively. After adjusting for risk factors, P/S and P-S correlated with carotid plaque [for low P/S: OR (95% CI): 3.15 (1.47– 6.73), P = 0.0031; for low P-S: OR (95% CI): 2.84 (1.42– 5.66), P = 0.0031] as well as carotid hypoechoic plaque [for low P/S: OR (95% CI): 1.82 (1.07– 3.08), P = 0.0259; for low P-S: OR (95% CI): 1.82 (1.09– 3.02), P = 0.021].Conclusion: T2DM patients with hypoechoic carotid plaque have higher pancreatic fat content than those without. Pancreatic steatosis correlates with carotid plaque and hypoechoic plaque in T2DM patients.Keywords: atherosclerosis, computed tomography, diabetes mellitus, pancreatic steatosisSun PFan CWang RChu TSun XZhang DDu XDove Medical Pressarticleatherosclerosiscomputed tomographydiabetes mellituspancreatic steatosisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1329-1337 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis computed tomography diabetes mellitus pancreatic steatosis Specialties of internal medicine RC581-951
spellingShingle	atherosclerosis computed tomography diabetes mellitus pancreatic steatosis Specialties of internal medicine RC581-951 Sun P Fan C Wang R Chu T Sun X Zhang D Du X Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
description	Pengtao Sun,1,* Chunzhi Fan,2,* Rengui Wang,1 Tongwei Chu,3 Xiaoli Sun,1 Dongxue Zhang,4 Xuechao Du5 1Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 2Department of Ultrasound Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 3Department of Ultrasound, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 4Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 5Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuechao DuDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, 5 Jingyuan Road, Shijingshan District, Beijing, 100043, People’s Republic of ChinaTel +86 13552588221Email duxuechao@ccmu.edu.cnObjective: To explore potential effects of pancreatic fat content measured by computed  tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Methods: T2DM patients who underwent an un-enhanced CT scan of the upper abdomen and ultrasound of the carotid artery were enrolled. The patients were divided into a non-plaque group and a plaque group (including hypoechoic plaque subgroup and non-hypoechoic plaque subgroup). The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and the difference between pancreatic and splenic attenuation (P-S) were calculated. The cutoff values of P/S and P-S were obtained using receiver operating characteristic curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque.Results: 337 patients were enrolled, including 101 cases in the non-plaque group, 146 cases in the hypoechoic plaque subgroup, and 90 cases in the non-hypoechoic plaque subgroup. P/S and P-S in hypoechoic plaque group were lower than those in non-plaque group, with a cutoff value of P/S and P-S as 0.72 and − 13.33, respectively. After adjusting for risk factors, P/S and P-S correlated with carotid plaque [for low P/S: OR (95% CI): 3.15 (1.47– 6.73), P = 0.0031; for low P-S: OR (95% CI): 2.84 (1.42– 5.66), P = 0.0031] as well as carotid hypoechoic plaque [for low P/S: OR (95% CI): 1.82 (1.07– 3.08), P = 0.0259; for low P-S: OR (95% CI): 1.82 (1.09– 3.02), P = 0.021].Conclusion: T2DM patients with hypoechoic carotid plaque have higher pancreatic fat content than those without. Pancreatic steatosis correlates with carotid plaque and hypoechoic plaque in T2DM patients.Keywords: atherosclerosis, computed tomography, diabetes mellitus, pancreatic steatosis
format	article
author	Sun P Fan C Wang R Chu T Sun X Zhang D Du X
author_facet	Sun P Fan C Wang R Chu T Sun X Zhang D Du X
author_sort	Sun P
title	Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
title_short	Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
title_full	Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
title_fullStr	Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
title_full_unstemmed	Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China
title_sort	computed tomography-estimated pancreatic steatosis is associated with carotid plaque in type 2 diabetes mellitus patients: a cross-sectional study from china
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c75b7115f570491fbefe61500454b4ac
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Computed Tomography-Estimated Pancreatic Steatosis is Associated with Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from China

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