Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children

Background:Recalcitrant molluscum contagiosum in children has been treated with many destructive procedures with a high recurrence rate, alternative treatments would be desirable in pediatric patients. Oral isotretinoin has been used to treat viral warts successfully in children. Aim of the work: Ou...

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Autores principales:	Rahma Ramdan, Hany Abou Alwafa, Emad Eldin Elgamal
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	isotretinoin molluscum contagiosum children Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c75da61d8e434a95bd49027764ed73d0
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spelling	oai:doaj.org-article:c75da61d8e434a95bd49027764ed73d02021-12-02T17:05:59ZOral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children2636-41742682-378010.21608/ijma.2021.71160.1293https://doaj.org/article/c75da61d8e434a95bd49027764ed73d02021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_174076_3e94fb852d82ad04eee3d370267169e3.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background:Recalcitrant molluscum contagiosum in children has been treated with many destructive procedures with a high recurrence rate, alternative treatments would be desirable in pediatric patients. Oral isotretinoin has been used to treat viral warts successfully in children. Aim of the work: Our aim in this study wasto investigate the influence of oral isotretinoin in MC patients. Methods: Twenty children less than 18 years, with recalcitrant molluscum contagiosum were enrolled in this study, the treatment protocol was oral isotretinoin [0.5 mg/kg] daily until complete clearance [maximum duration 3 months]. Patients were evaluated clinically and photographically every two weeks to assess the response to treatment and to report side effects of therapy. Patients with complete response were followed up monthly for three months to record the recurrence rate. Lipid profile [Triglycerides, cholesterol, LDL and HDL] and liver function tests [SGOT and SGPT] were performed before treatment and every 4 weeks during the treatment period. Results:Mean age of participants was 12.90 ± 2.64 years, 80% of them were more than 10 years old, [65%] were male, and the mean weight of studied cases was 49.10 ± 15.33 kg. The face was most common affected site in most cases [45%]. The mean lesion size was 2.63 ± 1.11 mm, and mean number of molluscum lesions of 23.55 ± 12.85. As regarding to recurrence rate, 93.8% of cases who had complete response were still free at the end of 3 months follow up and only 6.3% had recurrence. Reported side effects were dry lips in all participants, 55% had a dry skin and 30% had a dry nose. Conclusion: Oral isotretinoin therapy improves recalcitrant MC lesions in children, which maycontribute to its therapeutic efficacy.Rahma RamdanHany Abou AlwafaEmad Eldin ElgamalAl-Azhar University, Faculty of Medicine (Damietta)articleisotretinoinmolluscum contagiosumchildrenMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1598-1601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	isotretinoin molluscum contagiosum children Medicine (General) R5-920
spellingShingle	isotretinoin molluscum contagiosum children Medicine (General) R5-920 Rahma Ramdan Hany Abou Alwafa Emad Eldin Elgamal Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
description	Background:Recalcitrant molluscum contagiosum in children has been treated with many destructive procedures with a high recurrence rate, alternative treatments would be desirable in pediatric patients. Oral isotretinoin has been used to treat viral warts successfully in children. Aim of the work: Our aim in this study wasto investigate the influence of oral isotretinoin in MC patients. Methods: Twenty children less than 18 years, with recalcitrant molluscum contagiosum were enrolled in this study, the treatment protocol was oral isotretinoin [0.5 mg/kg] daily until complete clearance [maximum duration 3 months]. Patients were evaluated clinically and photographically every two weeks to assess the response to treatment and to report side effects of therapy. Patients with complete response were followed up monthly for three months to record the recurrence rate. Lipid profile [Triglycerides, cholesterol, LDL and HDL] and liver function tests [SGOT and SGPT] were performed before treatment and every 4 weeks during the treatment period. Results:Mean age of participants was 12.90 ± 2.64 years, 80% of them were more than 10 years old, [65%] were male, and the mean weight of studied cases was 49.10 ± 15.33 kg. The face was most common affected site in most cases [45%]. The mean lesion size was 2.63 ± 1.11 mm, and mean number of molluscum lesions of 23.55 ± 12.85. As regarding to recurrence rate, 93.8% of cases who had complete response were still free at the end of 3 months follow up and only 6.3% had recurrence. Reported side effects were dry lips in all participants, 55% had a dry skin and 30% had a dry nose. Conclusion: Oral isotretinoin therapy improves recalcitrant MC lesions in children, which maycontribute to its therapeutic efficacy.
format	article
author	Rahma Ramdan Hany Abou Alwafa Emad Eldin Elgamal
author_facet	Rahma Ramdan Hany Abou Alwafa Emad Eldin Elgamal
author_sort	Rahma Ramdan
title	Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
title_short	Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
title_full	Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
title_fullStr	Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
title_full_unstemmed	Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children
title_sort	oral isotretinoin in the treatment of recalcitrant molluscum contagiosum in children
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/c75da61d8e434a95bd49027764ed73d0
work_keys_str_mv	AT rahmaramdan oralisotretinoininthetreatmentofrecalcitrantmolluscumcontagiosuminchildren AT hanyaboualwafa oralisotretinoininthetreatmentofrecalcitrantmolluscumcontagiosuminchildren AT emadeldinelgamal oralisotretinoininthetreatmentofrecalcitrantmolluscumcontagiosuminchildren
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Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children

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