Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study

Background: Dyslipidemia is an important risk factor that can lead to the progression of retinopathy (DR). Diabetic dyslipidemia with low high-density lipoprotein (HDL) and increased triglycerides (TGs) are seen frequently among Type 2 diabetic mellitus. Aims and Objectives: (1) To assess the level...

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Autores principales:	Kalaimamani Ezhilvendhan, Anitha Sathiyamoorthy, B Jey Prakash, B Saravana Bhava, Arjun Shenoy
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	diabetic mellitus dyslipidemia early treatment diabetic retinopathy study Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/c75dade77d1c471286dff423826b2513
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spelling	oai:doaj.org-article:c75dade77d1c471286dff423826b25132021-11-19T12:15:52ZAssociation of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study0975-740610.4103/jpbs.jpbs_164_21https://doaj.org/article/c75dade77d1c471286dff423826b25132021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1062;epage=1067;aulast=Ezhilvendhanhttps://doaj.org/toc/0975-7406Background: Dyslipidemia is an important risk factor that can lead to the progression of retinopathy (DR). Diabetic dyslipidemia with low high-density lipoprotein (HDL) and increased triglycerides (TGs) are seen frequently among Type 2 diabetic mellitus. Aims and Objectives: (1) To assess the level of serum lipids (total cholesterol, TGs, HDL, and low-density lipoprotein [LDL]) among type 2 diabetes patients. (2) To determine the association between serum lipid levels and DR. Materials and Methods: This was a hospital-based cross-sectional study conducted in a tertiary care hospital in Salem from September 2018 to March 2020 with a sample size of 200. Details of their diabetic history were obtained. Patients were evaluated for their HbA1C levels, hypertension, and lipid profile status. Early treatment DR Study system was used to classify DR. Low density lipoprotein cholesterol was calculated by Freidewald's equation. Results: This study showed a significant association among DR and LDL cholesterol. DR with raised LDL, TGs levels, and lowered HDL on adjusted analysis. There was strong association between DR and serum cholesterol in unadjusted analysis; however, there was no association when adjusted for factors such as age, gender, duration of diabetes, and glycemic control. Majority of participants were males (57.5%) with a male: female = 1.35:1. The mean age of the patients in our study was 57.8 (5.8) years and 54.4 (6.6) years in patients with DR and patients without retinopathy, and it was found to be statistically significant. There was a significant difference in the duration of diabetes with the presence of DR and the patients with DR were having longer duration of diabetes (7.9 vs. 6.2 years; P < 0.001). Moderate nonproliferative diabetic retinopathy (NPDR) was found to be present in 41.0% of eyes followed by mild NPDR (20.5% eyes). Proliferative diabetic retinopathy was present only in 9.5%, and the severity of retinopathy was associated only with the HDL level, and there was no association found with total cholesterol, TG, and LDL cholesterol. Conclusion: A statistically significant correlation was found between dyslipidemia and the severity of DR among Type 2 diabetic patients.Kalaimamani EzhilvendhanAnitha SathiyamoorthyB Jey PrakashB Saravana BhavaArjun ShenoyWolters Kluwer Medknow Publicationsarticlediabetic mellitusdyslipidemiaearly treatment diabetic retinopathy studyPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1062-1067 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic mellitus dyslipidemia early treatment diabetic retinopathy study Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	diabetic mellitus dyslipidemia early treatment diabetic retinopathy study Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Kalaimamani Ezhilvendhan Anitha Sathiyamoorthy B Jey Prakash B Saravana Bhava Arjun Shenoy Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
description	Background: Dyslipidemia is an important risk factor that can lead to the progression of retinopathy (DR). Diabetic dyslipidemia with low high-density lipoprotein (HDL) and increased triglycerides (TGs) are seen frequently among Type 2 diabetic mellitus. Aims and Objectives: (1) To assess the level of serum lipids (total cholesterol, TGs, HDL, and low-density lipoprotein [LDL]) among type 2 diabetes patients. (2) To determine the association between serum lipid levels and DR. Materials and Methods: This was a hospital-based cross-sectional study conducted in a tertiary care hospital in Salem from September 2018 to March 2020 with a sample size of 200. Details of their diabetic history were obtained. Patients were evaluated for their HbA1C levels, hypertension, and lipid profile status. Early treatment DR Study system was used to classify DR. Low density lipoprotein cholesterol was calculated by Freidewald's equation. Results: This study showed a significant association among DR and LDL cholesterol. DR with raised LDL, TGs levels, and lowered HDL on adjusted analysis. There was strong association between DR and serum cholesterol in unadjusted analysis; however, there was no association when adjusted for factors such as age, gender, duration of diabetes, and glycemic control. Majority of participants were males (57.5%) with a male: female = 1.35:1. The mean age of the patients in our study was 57.8 (5.8) years and 54.4 (6.6) years in patients with DR and patients without retinopathy, and it was found to be statistically significant. There was a significant difference in the duration of diabetes with the presence of DR and the patients with DR were having longer duration of diabetes (7.9 vs. 6.2 years; P < 0.001). Moderate nonproliferative diabetic retinopathy (NPDR) was found to be present in 41.0% of eyes followed by mild NPDR (20.5% eyes). Proliferative diabetic retinopathy was present only in 9.5%, and the severity of retinopathy was associated only with the HDL level, and there was no association found with total cholesterol, TG, and LDL cholesterol. Conclusion: A statistically significant correlation was found between dyslipidemia and the severity of DR among Type 2 diabetic patients.
format	article
author	Kalaimamani Ezhilvendhan Anitha Sathiyamoorthy B Jey Prakash B Saravana Bhava Arjun Shenoy
author_facet	Kalaimamani Ezhilvendhan Anitha Sathiyamoorthy B Jey Prakash B Saravana Bhava Arjun Shenoy
author_sort	Kalaimamani Ezhilvendhan
title	Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
title_short	Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
title_full	Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
title_fullStr	Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
title_full_unstemmed	Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study
title_sort	association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: a hospital-based study
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/c75dade77d1c471286dff423826b2513
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Association of dyslipidemia with diabetic retinopathy in type 2 diabetes mellitus patients: A hospital-based study

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