Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion

Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune respo...

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Autores principales:	Xiu-Zhong Zhang, Fu-Huang Li, Xiao-Jia Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TRIM proteins type I interferon NF-kappa B immune evasion signaling pathways immune response Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c7610875f8464d808b4a4d84f7779612
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spelling	oai:doaj.org-article:c7610875f8464d808b4a4d84f77796122021-12-01T23:21:13ZRegulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion1664-302X10.3389/fmicb.2021.794882https://doaj.org/article/c7610875f8464d808b4a4d84f77796122021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.794882/fullhttps://doaj.org/toc/1664-302XTripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune responses via type I interferon, NF-κB, Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Nrf2. However, viruses are able to antagonize TRIM activity or evenly utilize TRIMs for viral replication. This communication presents the current understanding of TRIMs exploited by viruses to evade host immune response.Xiu-Zhong ZhangFu-Huang LiXiao-Jia WangFrontiers Media S.A.articleTRIM proteinstype I interferonNF-kappa Bimmune evasionsignaling pathwaysimmune responseMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRIM proteins type I interferon NF-kappa B immune evasion signaling pathways immune response Microbiology QR1-502
spellingShingle	TRIM proteins type I interferon NF-kappa B immune evasion signaling pathways immune response Microbiology QR1-502 Xiu-Zhong Zhang Fu-Huang Li Xiao-Jia Wang Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
description	Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells. TRIMs play important roles in modulating signaling pathways of antiviral immune responses via type I interferon, NF-κB, Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Nrf2. However, viruses are able to antagonize TRIM activity or evenly utilize TRIMs for viral replication. This communication presents the current understanding of TRIMs exploited by viruses to evade host immune response.
format	article
author	Xiu-Zhong Zhang Fu-Huang Li Xiao-Jia Wang
author_facet	Xiu-Zhong Zhang Fu-Huang Li Xiao-Jia Wang
author_sort	Xiu-Zhong Zhang
title	Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
title_short	Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
title_full	Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
title_fullStr	Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
title_full_unstemmed	Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
title_sort	regulation of tripartite motif-containing proteins on immune response and viral evasion
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c7610875f8464d808b4a4d84f7779612
work_keys_str_mv	AT xiuzhongzhang regulationoftripartitemotifcontainingproteinsonimmuneresponseandviralevasion AT fuhuangli regulationoftripartitemotifcontainingproteinsonimmuneresponseandviralevasion AT xiaojiawang regulationoftripartitemotifcontainingproteinsonimmuneresponseandviralevasion
_version_	1718404012567429120

Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion

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