Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect

Xiaotong Song,1,2 Ning Sun,1– 3 Aixia Zhang,1– 3 Lei Lei,1 Xinrong Li,1 Zhifen Liu,1– 3 Yanfang Wang,1 Chunxia Yang,1– 3 Kerang Zhang1 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Laboratory of Artificial Intelligence Assisted Diagnosi...

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Autores principales:	Song X, Sun N, Zhang A, Lei L, Li X, Liu Z, Wang Y, Yang C, Zhang K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	major depressive disorder nr4a2 single nucleotide polymorphism antidepressant treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c769bf800e0a4096a2801d4523fcb534
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spelling	oai:doaj.org-article:c769bf800e0a4096a2801d4523fcb5342021-12-02T16:38:15ZAssociation Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect1178-2021https://doaj.org/article/c769bf800e0a4096a2801d4523fcb5342021-08-01T00:00:00Zhttps://www.dovepress.com/association-between-nr4a2-gene-polymorphism-and-depressive-symptoms-an-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Xiaotong Song,1,2 Ning Sun,1– 3 Aixia Zhang,1– 3 Lei Lei,1 Xinrong Li,1 Zhifen Liu,1– 3 Yanfang Wang,1 Chunxia Yang,1– 3 Kerang Zhang1 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Mental Health, Shanxi Medical University, Taiyuan, People’s Republic of ChinaCorrespondence: Chunxia Yang; Kerang ZhangDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaEmail ychunxia2000@163.com; atomsxmu@vip.163.comObjective: Although the pathogenesis of major depressive disorder (MDD) is still unclear, studies have shown that the dopaminergic system of depressed patients is defective, and that NR4A2 is an important transcription factor affecting the development and maintenance of dopaminergic neurons. As such, NR4A2 levels affected by NR4A2 single nucleotide polymorphisms (SNPs) may be associated with MDD. This study examined whether NR4A2 SNPs are associated with depressive symptoms and antidepressant efficacy.Methods: A total of 441 patients with first-episode depression were enrolled in this study. We analysed three SNPs of NR4A2, using the 17-item Hamilton Depression Rating Scale (HAM-D) and its four factors to obtain scores at baseline and at the end of 6 weeks. UNPHASED software was employed for quantitative character analysis, and SPSS software was adopted for antidepressant efficacy analysis.Results: Patients with rs12803-A exhibited higher scores of retardation symptoms. Patients with the rs834834-C allele and rs834834-CC genotype had higher retardation symptom scores. Patients with rs3769340 exhibited greater antidepressant efficacy.Conclusion: NR4A2 gene polymorphisms are associated with retardation symptoms, somatic symptoms (gastro-intestinal), anxiety-based somatic symptoms, insight, and weight loss in patients with MDD. Additionally, rs3769340 may be a predictor of antidepressant efficacy in patients with major depressive disorder.Keywords: major depressive disorder, NR4A2, single nucleotide polymorphism, antidepressant treatmentSong XSun NZhang ALei LLi XLiu ZWang YYang CZhang KDove Medical Pressarticlemajor depressive disordernr4a2single nucleotide polymorphismantidepressant treatmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2613-2623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder nr4a2 single nucleotide polymorphism antidepressant treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder nr4a2 single nucleotide polymorphism antidepressant treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Song X Sun N Zhang A Lei L Li X Liu Z Wang Y Yang C Zhang K Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
description	Xiaotong Song,1,2 Ning Sun,1– 3 Aixia Zhang,1– 3 Lei Lei,1 Xinrong Li,1 Zhifen Liu,1– 3 Yanfang Wang,1 Chunxia Yang,1– 3 Kerang Zhang1 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Mental Health, Shanxi Medical University, Taiyuan, People’s Republic of ChinaCorrespondence: Chunxia Yang; Kerang ZhangDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaEmail ychunxia2000@163.com; atomsxmu@vip.163.comObjective: Although the pathogenesis of major depressive disorder (MDD) is still unclear, studies have shown that the dopaminergic system of depressed patients is defective, and that NR4A2 is an important transcription factor affecting the development and maintenance of dopaminergic neurons. As such, NR4A2 levels affected by NR4A2 single nucleotide polymorphisms (SNPs) may be associated with MDD. This study examined whether NR4A2 SNPs are associated with depressive symptoms and antidepressant efficacy.Methods: A total of 441 patients with first-episode depression were enrolled in this study. We analysed three SNPs of NR4A2, using the 17-item Hamilton Depression Rating Scale (HAM-D) and its four factors to obtain scores at baseline and at the end of 6 weeks. UNPHASED software was employed for quantitative character analysis, and SPSS software was adopted for antidepressant efficacy analysis.Results: Patients with rs12803-A exhibited higher scores of retardation symptoms. Patients with the rs834834-C allele and rs834834-CC genotype had higher retardation symptom scores. Patients with rs3769340 exhibited greater antidepressant efficacy.Conclusion: NR4A2 gene polymorphisms are associated with retardation symptoms, somatic symptoms (gastro-intestinal), anxiety-based somatic symptoms, insight, and weight loss in patients with MDD. Additionally, rs3769340 may be a predictor of antidepressant efficacy in patients with major depressive disorder.Keywords: major depressive disorder, NR4A2, single nucleotide polymorphism, antidepressant treatment
format	article
author	Song X Sun N Zhang A Lei L Li X Liu Z Wang Y Yang C Zhang K
author_facet	Song X Sun N Zhang A Lei L Li X Liu Z Wang Y Yang C Zhang K
author_sort	Song X
title	Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
title_short	Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
title_full	Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
title_fullStr	Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
title_full_unstemmed	Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
title_sort	association between nr4a2 gene polymorphism and depressive symptoms and antidepressant effect
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c769bf800e0a4096a2801d4523fcb534
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Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect

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