Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads to adipocyte dysfunction via excess autophagic de...

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Autores principales:	Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, Shotaro Saita, Shuhei Nakamura, Hikari Takeshita, Mari Fujiwara, Yusuke Enokidani, Gota Yoshida, Keisuke Tabata, Maho Hamasaki, Akiko Kuma, Koichi Yamamoto, Iichiro Shimomura, Tamotsu Yoshimori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c769ddd694a94059b7f5b01f32cee145
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spelling	oai:doaj.org-article:c769ddd694a94059b7f5b01f32cee1452021-12-02T15:10:47ZAge-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy10.1038/s41467-020-17985-w2041-1723https://doaj.org/article/c769ddd694a94059b7f5b01f32cee1452020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17985-whttps://doaj.org/toc/2041-1723Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads to adipocyte dysfunction via excess autophagic degradation of SRC-1 and TIF2.Tadashi YamamuroTsuyoshi KawabataAtsunori FukuharaShotaro SaitaShuhei NakamuraHikari TakeshitaMari FujiwaraYusuke EnokidaniGota YoshidaKeisuke TabataMaho HamasakiAkiko KumaKoichi YamamotoIichiro ShimomuraTamotsu YoshimoriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tadashi Yamamuro Tsuyoshi Kawabata Atsunori Fukuhara Shotaro Saita Shuhei Nakamura Hikari Takeshita Mari Fujiwara Yusuke Enokidani Gota Yoshida Keisuke Tabata Maho Hamasaki Akiko Kuma Koichi Yamamoto Iichiro Shimomura Tamotsu Yoshimori Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
description	Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads to adipocyte dysfunction via excess autophagic degradation of SRC-1 and TIF2.
format	article
author	Tadashi Yamamuro Tsuyoshi Kawabata Atsunori Fukuhara Shotaro Saita Shuhei Nakamura Hikari Takeshita Mari Fujiwara Yusuke Enokidani Gota Yoshida Keisuke Tabata Maho Hamasaki Akiko Kuma Koichi Yamamoto Iichiro Shimomura Tamotsu Yoshimori
author_facet	Tadashi Yamamuro Tsuyoshi Kawabata Atsunori Fukuhara Shotaro Saita Shuhei Nakamura Hikari Takeshita Mari Fujiwara Yusuke Enokidani Gota Yoshida Keisuke Tabata Maho Hamasaki Akiko Kuma Koichi Yamamoto Iichiro Shimomura Tamotsu Yoshimori
author_sort	Tadashi Yamamuro
title	Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
title_short	Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
title_full	Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
title_fullStr	Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
title_full_unstemmed	Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
title_sort	age-dependent loss of adipose rubicon promotes metabolic disorders via excess autophagy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c769ddd694a94059b7f5b01f32cee145
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Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

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