SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES

The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte...

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Autor principal:	V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	autoimmunity suppressor cells homeostasis lymphocyte proliferation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c76a2358048a46ad901b133150ad9122
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spelling	oai:doaj.org-article:c76a2358048a46ad901b133150ad91222021-11-18T08:03:45ZSUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES1563-06252313-741X10.15789/1563-0625-2016-1-7-14https://doaj.org/article/c76a2358048a46ad901b133150ad91222016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/983https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte proliferation is considered to be of great importance for pathogenesis of autoimmune disorders. Recent data from literature suggest that the autoimmune diseases are characterized by reduced activity of the mentioned suppressor cell populations, thus being a possible prerequisite for development of autoaggressive clones of cytotoxic lymphocytes, increased synthesis of autoantibodies leading to evolving autoimmune pathology. It should be, however, noted, that all these processes are accompanied by changes in the immune system induced by homeostatic proliferation of lymphoid cells.V. A. KozlovSPb RAACIarticleautoimmunitysuppressor cellshomeostasislymphocyte proliferationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 1, Pp 7-14 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmunity suppressor cells homeostasis lymphocyte proliferation Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmunity suppressor cells homeostasis lymphocyte proliferation Immunologic diseases. Allergy RC581-607 V. A. Kozlov SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
description	The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte proliferation is considered to be of great importance for pathogenesis of autoimmune disorders. Recent data from literature suggest that the autoimmune diseases are characterized by reduced activity of the mentioned suppressor cell populations, thus being a possible prerequisite for development of autoaggressive clones of cytotoxic lymphocytes, increased synthesis of autoantibodies leading to evolving autoimmune pathology. It should be, however, noted, that all these processes are accompanied by changes in the immune system induced by homeostatic proliferation of lymphoid cells.
format	article
author	V. A. Kozlov
author_facet	V. A. Kozlov
author_sort	V. A. Kozlov
title	SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
title_short	SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
title_full	SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
title_fullStr	SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
title_full_unstemmed	SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
title_sort	suppressor cells – the basis of immunopathogenesis autoimmune diseases
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/c76a2358048a46ad901b133150ad9122
work_keys_str_mv	AT vakozlov suppressorcellsthebasisofimmunopathogenesisautoimmunediseases
_version_	1718422446275559424

SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES

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