Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

During clathrin-mediated endocytosis in yeast, endocytic coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for membrane invagination. Here authors present a cryo-EM structure of a 16-mer complex of the ANTH and ENTH membr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Javier Lizarrondo, David P. Klebl, Stephan Niebling, Marc Abella, Martin A. Schroer, Haydyn D. T. Mertens, Katharina Veith, Roland Thuenauer, Dmitri I. Svergun, Michal Skruzny, Frank Sobott, Stephen P. Muench, Maria M. Garcia-Alai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c76a9156443143ecaad0091e2cec9c08
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c76a9156443143ecaad0091e2cec9c08
record_format	dspace
spelling	oai:doaj.org-article:c76a9156443143ecaad0091e2cec9c082021-12-02T14:58:43ZStructure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis10.1038/s41467-021-23151-72041-1723https://doaj.org/article/c76a9156443143ecaad0091e2cec9c082021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23151-7https://doaj.org/toc/2041-1723During clathrin-mediated endocytosis in yeast, endocytic coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for membrane invagination. Here authors present a cryo-EM structure of a 16-mer complex of the ANTH and ENTH membrane-binding domains from Sla2 and Ent1 bound to PIP2 that constitutes the anchor to the plasma membrane.Javier LizarrondoDavid P. KleblStephan NieblingMarc AbellaMartin A. SchroerHaydyn D. T. MertensKatharina VeithRoland ThuenauerDmitri I. SvergunMichal SkruznyFrank SobottStephen P. MuenchMaria M. Garcia-AlaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Lizarrondo David P. Klebl Stephan Niebling Marc Abella Martin A. Schroer Haydyn D. T. Mertens Katharina Veith Roland Thuenauer Dmitri I. Svergun Michal Skruzny Frank Sobott Stephen P. Muench Maria M. Garcia-Alai Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
description	During clathrin-mediated endocytosis in yeast, endocytic coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for membrane invagination. Here authors present a cryo-EM structure of a 16-mer complex of the ANTH and ENTH membrane-binding domains from Sla2 and Ent1 bound to PIP2 that constitutes the anchor to the plasma membrane.
format	article
author	Javier Lizarrondo David P. Klebl Stephan Niebling Marc Abella Martin A. Schroer Haydyn D. T. Mertens Katharina Veith Roland Thuenauer Dmitri I. Svergun Michal Skruzny Frank Sobott Stephen P. Muench Maria M. Garcia-Alai
author_facet	Javier Lizarrondo David P. Klebl Stephan Niebling Marc Abella Martin A. Schroer Haydyn D. T. Mertens Katharina Veith Roland Thuenauer Dmitri I. Svergun Michal Skruzny Frank Sobott Stephen P. Muench Maria M. Garcia-Alai
author_sort	Javier Lizarrondo
title	Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
title_short	Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
title_full	Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
title_fullStr	Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
title_full_unstemmed	Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
title_sort	structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c76a9156443143ecaad0091e2cec9c08
work_keys_str_mv	AT javierlizarrondo structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT davidpklebl structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT stephanniebling structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT marcabella structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT martinaschroer structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT haydyndtmertens structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT katharinaveith structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT rolandthuenauer structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT dmitriisvergun structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT michalskruzny structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT franksobott structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT stephenpmuench structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis AT mariamgarciaalai structureoftheendocyticadaptorcomplexrevealsthebasisforefficientmembraneanchoringduringclathrinmediatedendocytosis
_version_	1718389289544318976

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

Ejemplares similares