Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions

Abstract Background A variety of bone graft substitutes have been introduced into the treatment of bone non-unions. However, clinical outcomes from current evidences are various and conflicting. This study aimed to present the preliminary outcomes of a treatment protocol in which the combination of...

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Autores principales:	Wei Nie, Zhaojun Wang, Jiaqing Cao, Wei Wang, Yanjie Guo, Chi Zhang, Weitao Jia, Xiaolin Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Demineralized bone matrix (DBM) Platelet rich plasma (PRP) Bone non-unions Surgical treatment Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/c76ae56ba88e437da4192bc18c388cc9
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spelling	oai:doaj.org-article:c76ae56ba88e437da4192bc18c388cc92021-11-21T12:27:55ZPreliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions10.1186/s12891-021-04840-21471-2474https://doaj.org/article/c76ae56ba88e437da4192bc18c388cc92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12891-021-04840-2https://doaj.org/toc/1471-2474Abstract Background A variety of bone graft substitutes have been introduced into the treatment of bone non-unions. However, clinical outcomes from current evidences are various and conflicting. This study aimed to present the preliminary outcomes of a treatment protocol in which the combination of demineralized bone matrix (DBM) and platelet rich plasma (PRP) was used as a bone graft substitute for long bone non-unions. Methods Data of this retrospective study were reviewed and collected from a consecutive case series involving 43 patients who presented with a long bone non-union and were treated in our department from October 2018 to May 2019. The combination of DMB and PRP was applied as a bone defect filler in 16 patients, whilst the other 27 patients were treated with iliac bone autografting. Patients’ demographics, postoperative complications and the result of bone union were compared and evaluated. Results The demographic data between the two groups were comparable. No significant difference was found with regard to the incidence of postoperative complications. No graft rejection, heterotopic ossification or other complications were noted. The distribution of bony healing time was rather scattered but did not differ significantly between the groups (7.533 ± 3.357 months vs. 6.625 ± 2.516 months; P=0.341). Union was identified radiographically in 15 of 16 patients in the DBM+PRP group and in 24 of 27 patients in autograft group. Conclusions The present study identified that low incidence of postoperative complications and satisfactory bony healing rate could be achieved in the treatment of long bone non-unions augmented with the combination of DBM and PRP. Although these findings might indicate the promising future of this treatment protocol, larger and higher quality studies should also be executed to assess its routine use.Wei NieZhaojun WangJiaqing CaoWei WangYanjie GuoChi ZhangWeitao JiaXiaolin LiBMCarticleDemineralized bone matrix (DBM)Platelet rich plasma (PRP)Bone non-unionsSurgical treatmentDiseases of the musculoskeletal systemRC925-935ENBMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Demineralized bone matrix (DBM) Platelet rich plasma (PRP) Bone non-unions Surgical treatment Diseases of the musculoskeletal system RC925-935
spellingShingle	Demineralized bone matrix (DBM) Platelet rich plasma (PRP) Bone non-unions Surgical treatment Diseases of the musculoskeletal system RC925-935 Wei Nie Zhaojun Wang Jiaqing Cao Wei Wang Yanjie Guo Chi Zhang Weitao Jia Xiaolin Li Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
description	Abstract Background A variety of bone graft substitutes have been introduced into the treatment of bone non-unions. However, clinical outcomes from current evidences are various and conflicting. This study aimed to present the preliminary outcomes of a treatment protocol in which the combination of demineralized bone matrix (DBM) and platelet rich plasma (PRP) was used as a bone graft substitute for long bone non-unions. Methods Data of this retrospective study were reviewed and collected from a consecutive case series involving 43 patients who presented with a long bone non-union and were treated in our department from October 2018 to May 2019. The combination of DMB and PRP was applied as a bone defect filler in 16 patients, whilst the other 27 patients were treated with iliac bone autografting. Patients’ demographics, postoperative complications and the result of bone union were compared and evaluated. Results The demographic data between the two groups were comparable. No significant difference was found with regard to the incidence of postoperative complications. No graft rejection, heterotopic ossification or other complications were noted. The distribution of bony healing time was rather scattered but did not differ significantly between the groups (7.533 ± 3.357 months vs. 6.625 ± 2.516 months; P=0.341). Union was identified radiographically in 15 of 16 patients in the DBM+PRP group and in 24 of 27 patients in autograft group. Conclusions The present study identified that low incidence of postoperative complications and satisfactory bony healing rate could be achieved in the treatment of long bone non-unions augmented with the combination of DBM and PRP. Although these findings might indicate the promising future of this treatment protocol, larger and higher quality studies should also be executed to assess its routine use.
format	article
author	Wei Nie Zhaojun Wang Jiaqing Cao Wei Wang Yanjie Guo Chi Zhang Weitao Jia Xiaolin Li
author_facet	Wei Nie Zhaojun Wang Jiaqing Cao Wei Wang Yanjie Guo Chi Zhang Weitao Jia Xiaolin Li
author_sort	Wei Nie
title	Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
title_short	Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
title_full	Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
title_fullStr	Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
title_full_unstemmed	Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions
title_sort	preliminary outcomes of the combination of demineralized bone matrix and platelet rich plasma in the treatment of long bone non-unions
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c76ae56ba88e437da4192bc18c388cc9
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Preliminary outcomes of the combination of demineralized bone matrix and platelet Rich plasma in the treatment of long bone non-unions

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