Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Functionalization of carbon radicals formed via 1,5-hydrogen atom transfer of amidyl radicals is an underdeveloped protocol for remote C–H functionalization. Here, the authors report a Cu-catalyzed γ-azidation and oxidative δ-trifluoromethylation of benzohydrazides for the synthesis of more function...

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Autores principales:	Xu Bao, Qian Wang, Jieping Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c76c407eb46048cbb73fd7dfe181a859
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spelling	oai:doaj.org-article:c76c407eb46048cbb73fd7dfe181a8592021-12-02T14:39:03ZCopper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides10.1038/s41467-019-08741-w2041-1723https://doaj.org/article/c76c407eb46048cbb73fd7dfe181a8592019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08741-whttps://doaj.org/toc/2041-1723Functionalization of carbon radicals formed via 1,5-hydrogen atom transfer of amidyl radicals is an underdeveloped protocol for remote C–H functionalization. Here, the authors report a Cu-catalyzed γ-azidation and oxidative δ-trifluoromethylation of benzohydrazides for the synthesis of more functionalized amides.Xu BaoQian WangJieping ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xu Bao Qian Wang Jieping Zhu Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
description	Functionalization of carbon radicals formed via 1,5-hydrogen atom transfer of amidyl radicals is an underdeveloped protocol for remote C–H functionalization. Here, the authors report a Cu-catalyzed γ-azidation and oxidative δ-trifluoromethylation of benzohydrazides for the synthesis of more functionalized amides.
format	article
author	Xu Bao Qian Wang Jieping Zhu
author_facet	Xu Bao Qian Wang Jieping Zhu
author_sort	Xu Bao
title	Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
title_short	Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
title_full	Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
title_fullStr	Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
title_full_unstemmed	Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides
title_sort	copper-catalyzed remote c(sp 3)–h azidation and oxidative trifluoromethylation of benzohydrazides
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c76c407eb46048cbb73fd7dfe181a859
work_keys_str_mv	AT xubao coppercatalyzedremotecsp3hazidationandoxidativetrifluoromethylationofbenzohydrazides AT qianwang coppercatalyzedremotecsp3hazidationandoxidativetrifluoromethylationofbenzohydrazides AT jiepingzhu coppercatalyzedremotecsp3hazidationandoxidativetrifluoromethylationofbenzohydrazides
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Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides

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