UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

Retrotransposons are silenced by an epigenetic mechanism and piRNA pathway in the mammalian germline. Here, the authors report that UHRF1 suppresses retrotransposons by interacting with PRMT5 and PIWI proteins during spermatogenesis.

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Detalles Bibliográficos
Autores principales: Juan Dong, Xiaoli Wang, Congcong Cao, Yujiao Wen, Akihiko Sakashita, Si Chen, Jin Zhang, Yue Zhang, Liquan Zhou, Mengcheng Luo, Mingxi Liu, Aihua Liao, Satoshi H. Namekawa, Shuiqiao Yuan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/c76cb3c76543408a83107042b6b9f1d8
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