Alpha-Synuclein and Cognitive Decline in Parkinson Disease
Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms t...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c76dc22c2cfb48288f6dac28ad722335 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c76dc22c2cfb48288f6dac28ad722335 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c76dc22c2cfb48288f6dac28ad7223352021-11-25T18:11:28ZAlpha-Synuclein and Cognitive Decline in Parkinson Disease10.3390/life111112392075-1729https://doaj.org/article/c76dc22c2cfb48288f6dac28ad7223352021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1239https://doaj.org/toc/2075-1729Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.Tian-Sin FanSam Chi-Hao LiuRuey-Meei WuMDPI AGarticleParkinson diseasealpha-synucleincognitiondementianon-motor symptomLewy bodyScienceQENLife, Vol 11, Iss 1239, p 1239 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Parkinson disease alpha-synuclein cognition dementia non-motor symptom Lewy body Science Q |
| spellingShingle |
Parkinson disease alpha-synuclein cognition dementia non-motor symptom Lewy body Science Q Tian-Sin Fan Sam Chi-Hao Liu Ruey-Meei Wu Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| description |
Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement. |
| format |
article |
| author |
Tian-Sin Fan Sam Chi-Hao Liu Ruey-Meei Wu |
| author_facet |
Tian-Sin Fan Sam Chi-Hao Liu Ruey-Meei Wu |
| author_sort |
Tian-Sin Fan |
| title |
Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| title_short |
Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| title_full |
Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| title_fullStr |
Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| title_full_unstemmed |
Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
| title_sort |
alpha-synuclein and cognitive decline in parkinson disease |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c76dc22c2cfb48288f6dac28ad722335 |
| work_keys_str_mv |
AT tiansinfan alphasynucleinandcognitivedeclineinparkinsondisease AT samchihaoliu alphasynucleinandcognitivedeclineinparkinsondisease AT rueymeeiwu alphasynucleinandcognitivedeclineinparkinsondisease |
| _version_ |
1718411522709913600 |