Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activat...

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Autores principales: Travis T. Sims, Molly B. El Alam, Tatiana V. Karpinets, Stephanie Dorta-Estremera, Venkatesh L. Hegde, Sita Nookala, Kyoko Yoshida-Court, Xiaogang Wu, Greyson W. G. Biegert, Andrea Y. Delgado Medrano, Travis Solley, Mustapha Ahmed-Kaddar, Bhavana V. Chapman, K. Jagannadha Sastry, Melissa P. Mezzari, Joseph F. Petrosino, Lilie L. Lin, Lois Ramondetta, Anuja Jhingran, Kathleen M. Schmeler, Nadim J. Ajami, Jennifer Wargo, Lauren E. Colbert, Ann H. Klopp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c76ee253ea0f4e5b85dab20f72cbe758
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Sumario:Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ throughout radiation therapy. These results reveal how modulation of the gut microbiota could potentially be used to improve treatment efficacy and outcome.

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