Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation
Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activat...
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Nature Portfolio
2021
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oai:doaj.org-article:c76ee253ea0f4e5b85dab20f72cbe7582021-12-02T14:13:39ZGut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation10.1038/s42003-021-01741-x2399-3642https://doaj.org/article/c76ee253ea0f4e5b85dab20f72cbe7582021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01741-xhttps://doaj.org/toc/2399-3642Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ throughout radiation therapy. These results reveal how modulation of the gut microbiota could potentially be used to improve treatment efficacy and outcome.Travis T. SimsMolly B. El AlamTatiana V. KarpinetsStephanie Dorta-EstremeraVenkatesh L. HegdeSita NookalaKyoko Yoshida-CourtXiaogang WuGreyson W. G. BiegertAndrea Y. Delgado MedranoTravis SolleyMustapha Ahmed-KaddarBhavana V. ChapmanK. Jagannadha SastryMelissa P. MezzariJoseph F. PetrosinoLilie L. LinLois RamondettaAnuja JhingranKathleen M. SchmelerNadim J. AjamiJennifer WargoLauren E. ColbertAnn H. KloppNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Travis T. Sims Molly B. El Alam Tatiana V. Karpinets Stephanie Dorta-Estremera Venkatesh L. Hegde Sita Nookala Kyoko Yoshida-Court Xiaogang Wu Greyson W. G. Biegert Andrea Y. Delgado Medrano Travis Solley Mustapha Ahmed-Kaddar Bhavana V. Chapman K. Jagannadha Sastry Melissa P. Mezzari Joseph F. Petrosino Lilie L. Lin Lois Ramondetta Anuja Jhingran Kathleen M. Schmeler Nadim J. Ajami Jennifer Wargo Lauren E. Colbert Ann H. Klopp Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| description |
Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ throughout radiation therapy. These results reveal how modulation of the gut microbiota could potentially be used to improve treatment efficacy and outcome. |
| format |
article |
| author |
Travis T. Sims Molly B. El Alam Tatiana V. Karpinets Stephanie Dorta-Estremera Venkatesh L. Hegde Sita Nookala Kyoko Yoshida-Court Xiaogang Wu Greyson W. G. Biegert Andrea Y. Delgado Medrano Travis Solley Mustapha Ahmed-Kaddar Bhavana V. Chapman K. Jagannadha Sastry Melissa P. Mezzari Joseph F. Petrosino Lilie L. Lin Lois Ramondetta Anuja Jhingran Kathleen M. Schmeler Nadim J. Ajami Jennifer Wargo Lauren E. Colbert Ann H. Klopp |
| author_facet |
Travis T. Sims Molly B. El Alam Tatiana V. Karpinets Stephanie Dorta-Estremera Venkatesh L. Hegde Sita Nookala Kyoko Yoshida-Court Xiaogang Wu Greyson W. G. Biegert Andrea Y. Delgado Medrano Travis Solley Mustapha Ahmed-Kaddar Bhavana V. Chapman K. Jagannadha Sastry Melissa P. Mezzari Joseph F. Petrosino Lilie L. Lin Lois Ramondetta Anuja Jhingran Kathleen M. Schmeler Nadim J. Ajami Jennifer Wargo Lauren E. Colbert Ann H. Klopp |
| author_sort |
Travis T. Sims |
| title |
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| title_short |
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| title_full |
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| title_fullStr |
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| title_full_unstemmed |
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| title_sort |
gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c76ee253ea0f4e5b85dab20f72cbe758 |
| work_keys_str_mv |
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