MicroRNA dysregulation in B-cell non-Hodgkin lymphoma

Emilia L Lim,1 Marco A Marra1,21Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; 2Department of Medical Genetics, University of British Columbia, Vancouver, BC, CanadaAbstract: B-cell non-Hodgkin lymphomas (NHLs) are lymphoproliferative disorders that...

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Autores principales:	Lim EL, Marra MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/c7718520bab544ce82ae0420ba9d5cd7
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spelling	oai:doaj.org-article:c7718520bab544ce82ae0420ba9d5cd72021-12-02T09:05:35ZMicroRNA dysregulation in B-cell non-Hodgkin lymphoma1179-9889https://doaj.org/article/c7718520bab544ce82ae0420ba9d5cd72013-05-01T00:00:00Zhttp://www.dovepress.com/microrna-dysregulation-in-b-cell-non-hodgkin-lymphoma-a12988https://doaj.org/toc/1179-9889Emilia L Lim,1 Marco A Marra1,21Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; 2Department of Medical Genetics, University of British Columbia, Vancouver, BC, CanadaAbstract: B-cell non-Hodgkin lymphomas (NHLs) are lymphoproliferative disorders that can arise at different stages of B-cell development. Even though molecular classification of NHL has allowed for more accurate recognition of distinct aggressive lymphoma subtypes, many patients still fail to respond to standard therapy. As such, there is a need to identify biomarkers and therapeutic targets that can lead to more specific treatments for each NHL patient's disease. MicroRNAs (miRNAs) are small, 17–25 nt RNA molecules that regulate gene expression at the posttranscriptional level. miRNA expression and function is often coordinately dysregulated in NHL, and consequently results in each NHL disease type harboring a distinct miRNA expression signature. miRNA dysregulation may be a consequence of several mechanisms, ranging from dysregulation of the DNA sequences encoding the miRNA to transcriptional regulation of miRNA loci, to dysregulation of the miRNA biogenesis pathway or dysregulation of messenger RNA (mRNA) targets. This coordinated dysregulation of miRNA expression systematically results in the activation of several oncogenic pathways, and consequently the reprogramming of B-cell NHL transcriptomes. The widespread dysregulation of miRNAs suggests that miRNAs may be used as a diagnostic and prognostic tool, and also as actionable drug targets. In this review, we summarize the miRNA profiles of the most common B-cell NHLs, discuss the causes and consequences of miRNA dysregulation, and consider the prospects of miRNA-based biomarkers and therapeutic targets in NHL.Keywords: miRNA, non-Hodgkin lymphoma, dysregulation, therapyLim ELMarra MADove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2013, Iss default, Pp 25-40 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Lim EL Marra MA MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
description	Emilia L Lim,1 Marco A Marra1,21Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; 2Department of Medical Genetics, University of British Columbia, Vancouver, BC, CanadaAbstract: B-cell non-Hodgkin lymphomas (NHLs) are lymphoproliferative disorders that can arise at different stages of B-cell development. Even though molecular classification of NHL has allowed for more accurate recognition of distinct aggressive lymphoma subtypes, many patients still fail to respond to standard therapy. As such, there is a need to identify biomarkers and therapeutic targets that can lead to more specific treatments for each NHL patient's disease. MicroRNAs (miRNAs) are small, 17–25 nt RNA molecules that regulate gene expression at the posttranscriptional level. miRNA expression and function is often coordinately dysregulated in NHL, and consequently results in each NHL disease type harboring a distinct miRNA expression signature. miRNA dysregulation may be a consequence of several mechanisms, ranging from dysregulation of the DNA sequences encoding the miRNA to transcriptional regulation of miRNA loci, to dysregulation of the miRNA biogenesis pathway or dysregulation of messenger RNA (mRNA) targets. This coordinated dysregulation of miRNA expression systematically results in the activation of several oncogenic pathways, and consequently the reprogramming of B-cell NHL transcriptomes. The widespread dysregulation of miRNAs suggests that miRNAs may be used as a diagnostic and prognostic tool, and also as actionable drug targets. In this review, we summarize the miRNA profiles of the most common B-cell NHLs, discuss the causes and consequences of miRNA dysregulation, and consider the prospects of miRNA-based biomarkers and therapeutic targets in NHL.Keywords: miRNA, non-Hodgkin lymphoma, dysregulation, therapy
format	article
author	Lim EL Marra MA
author_facet	Lim EL Marra MA
author_sort	Lim EL
title	MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
title_short	MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
title_full	MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
title_fullStr	MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
title_full_unstemmed	MicroRNA dysregulation in B-cell non-Hodgkin lymphoma
title_sort	microrna dysregulation in b-cell non-hodgkin lymphoma
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c7718520bab544ce82ae0420ba9d5cd7
work_keys_str_mv	AT limel micrornadysregulationinbcellnonhodgkinlymphoma AT marrama micrornadysregulationinbcellnonhodgkinlymphoma
_version_	1718398270692130816

MicroRNA dysregulation in B-cell non-Hodgkin lymphoma

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