The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.
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Nature Portfolio
2020
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oai:doaj.org-article:c776838301d2406eb50617b6e0cb86a12021-12-02T15:39:23ZThe epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction10.1038/s41467-019-14082-52041-1723https://doaj.org/article/c776838301d2406eb50617b6e0cb86a12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14082-5https://doaj.org/toc/2041-1723The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.Maria Carmen IndaSuhasini JoshiTai WangAlexander BolaenderSrinivasa GanduJohn Koren IIIAlicia Yue CheTony TaldonePengrong YanWeilin SunMohammad UddinPalak PanchalMatthew RioloSmit ShahAfsar BarlasKe XuLon Yin L. ChanAlexandra GruzinovaSarah KishinevskyLorenz StuderValentina FossatiScott A. NoggleJulie R. WhiteElisa de StanchinaSonia SequeiraKyle H. AnthoneyJohn W. SteeleKatia Manova-TodorovaSujata PatilMark P. DunphyNagaVaraKishore PillarsettyAna C. PereiraHediye Erdjument-BromageThomas A. NeubertAnna RodinaStephen D. GinsbergNatalia De Marco GarciaWenjie LuoGabriela ChiosisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Maria Carmen Inda Suhasini Joshi Tai Wang Alexander Bolaender Srinivasa Gandu John Koren III Alicia Yue Che Tony Taldone Pengrong Yan Weilin Sun Mohammad Uddin Palak Panchal Matthew Riolo Smit Shah Afsar Barlas Ke Xu Lon Yin L. Chan Alexandra Gruzinova Sarah Kishinevsky Lorenz Studer Valentina Fossati Scott A. Noggle Julie R. White Elisa de Stanchina Sonia Sequeira Kyle H. Anthoney John W. Steele Katia Manova-Todorova Sujata Patil Mark P. Dunphy NagaVaraKishore Pillarsetty Ana C. Pereira Hediye Erdjument-Bromage Thomas A. Neubert Anna Rodina Stephen D. Ginsberg Natalia De Marco Garcia Wenjie Luo Gabriela Chiosis The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| description |
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics. |
| format |
article |
| author |
Maria Carmen Inda Suhasini Joshi Tai Wang Alexander Bolaender Srinivasa Gandu John Koren III Alicia Yue Che Tony Taldone Pengrong Yan Weilin Sun Mohammad Uddin Palak Panchal Matthew Riolo Smit Shah Afsar Barlas Ke Xu Lon Yin L. Chan Alexandra Gruzinova Sarah Kishinevsky Lorenz Studer Valentina Fossati Scott A. Noggle Julie R. White Elisa de Stanchina Sonia Sequeira Kyle H. Anthoney John W. Steele Katia Manova-Todorova Sujata Patil Mark P. Dunphy NagaVaraKishore Pillarsetty Ana C. Pereira Hediye Erdjument-Bromage Thomas A. Neubert Anna Rodina Stephen D. Ginsberg Natalia De Marco Garcia Wenjie Luo Gabriela Chiosis |
| author_facet |
Maria Carmen Inda Suhasini Joshi Tai Wang Alexander Bolaender Srinivasa Gandu John Koren III Alicia Yue Che Tony Taldone Pengrong Yan Weilin Sun Mohammad Uddin Palak Panchal Matthew Riolo Smit Shah Afsar Barlas Ke Xu Lon Yin L. Chan Alexandra Gruzinova Sarah Kishinevsky Lorenz Studer Valentina Fossati Scott A. Noggle Julie R. White Elisa de Stanchina Sonia Sequeira Kyle H. Anthoney John W. Steele Katia Manova-Todorova Sujata Patil Mark P. Dunphy NagaVaraKishore Pillarsetty Ana C. Pereira Hediye Erdjument-Bromage Thomas A. Neubert Anna Rodina Stephen D. Ginsberg Natalia De Marco Garcia Wenjie Luo Gabriela Chiosis |
| author_sort |
Maria Carmen Inda |
| title |
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| title_short |
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| title_full |
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| title_fullStr |
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| title_full_unstemmed |
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| title_sort |
epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c776838301d2406eb50617b6e0cb86a1 |
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