SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection observed 6 months post vaccination.

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Autores principales: Ramon Roozendaal, Laura Solforosi, Daniel J. Stieh, Jan Serroyen, Roel Straetemans, Anna Dari, Muriel Boulton, Frank Wegmann, Sietske K. Rosendahl Huber, Joan E. M. van der Lubbe, Jenny Hendriks, Mathieu Le Gars, Liesbeth Dekking, Dominika N. Czapska-Casey, Nuria Guimera, Sarah Janssen, Sarah Tete, Abishek Chandrashekar, Noe B. Mercado, Jingyou Yu, Wouter Koudstaal, Juan J. Perez-Ruixo, Jerry Sadoff, Dan H. Barouch, Hanneke Schuitemaker, Roland Zahn
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c77c130d228d404b88e0e8b1e5e20f78
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spelling oai:doaj.org-article:c77c130d228d404b88e0e8b1e5e20f782021-12-02T16:56:48ZSARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques10.1038/s41467-021-26117-x2041-1723https://doaj.org/article/c77c130d228d404b88e0e8b1e5e20f782021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26117-xhttps://doaj.org/toc/2041-1723Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection observed 6 months post vaccination.Ramon RoozendaalLaura SolforosiDaniel J. StiehJan SerroyenRoel StraetemansAnna DariMuriel BoultonFrank WegmannSietske K. Rosendahl HuberJoan E. M. van der LubbeJenny HendriksMathieu Le GarsLiesbeth DekkingDominika N. Czapska-CaseyNuria GuimeraSarah JanssenSarah TeteAbishek ChandrashekarNoe B. MercadoJingyou YuWouter KoudstaalJuan J. Perez-RuixoJerry SadoffDan H. BarouchHanneke SchuitemakerRoland ZahnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ramon Roozendaal
Laura Solforosi
Daniel J. Stieh
Jan Serroyen
Roel Straetemans
Anna Dari
Muriel Boulton
Frank Wegmann
Sietske K. Rosendahl Huber
Joan E. M. van der Lubbe
Jenny Hendriks
Mathieu Le Gars
Liesbeth Dekking
Dominika N. Czapska-Casey
Nuria Guimera
Sarah Janssen
Sarah Tete
Abishek Chandrashekar
Noe B. Mercado
Jingyou Yu
Wouter Koudstaal
Juan J. Perez-Ruixo
Jerry Sadoff
Dan H. Barouch
Hanneke Schuitemaker
Roland Zahn
SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
description Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection observed 6 months post vaccination.
format article
author Ramon Roozendaal
Laura Solforosi
Daniel J. Stieh
Jan Serroyen
Roel Straetemans
Anna Dari
Muriel Boulton
Frank Wegmann
Sietske K. Rosendahl Huber
Joan E. M. van der Lubbe
Jenny Hendriks
Mathieu Le Gars
Liesbeth Dekking
Dominika N. Czapska-Casey
Nuria Guimera
Sarah Janssen
Sarah Tete
Abishek Chandrashekar
Noe B. Mercado
Jingyou Yu
Wouter Koudstaal
Juan J. Perez-Ruixo
Jerry Sadoff
Dan H. Barouch
Hanneke Schuitemaker
Roland Zahn
author_facet Ramon Roozendaal
Laura Solforosi
Daniel J. Stieh
Jan Serroyen
Roel Straetemans
Anna Dari
Muriel Boulton
Frank Wegmann
Sietske K. Rosendahl Huber
Joan E. M. van der Lubbe
Jenny Hendriks
Mathieu Le Gars
Liesbeth Dekking
Dominika N. Czapska-Casey
Nuria Guimera
Sarah Janssen
Sarah Tete
Abishek Chandrashekar
Noe B. Mercado
Jingyou Yu
Wouter Koudstaal
Juan J. Perez-Ruixo
Jerry Sadoff
Dan H. Barouch
Hanneke Schuitemaker
Roland Zahn
author_sort Ramon Roozendaal
title SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
title_short SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
title_full SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
title_fullStr SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
title_full_unstemmed SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
title_sort sars-cov-2 binding and neutralizing antibody levels after ad26.cov2.s vaccination predict durable protection in rhesus macaques
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c77c130d228d404b88e0e8b1e5e20f78
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