Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in multiple immune cell populations including Th17 cells,...
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Public Library of Science (PLoS)
2021
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| Accès en ligne: | https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d |
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par Steven A Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D'Agostino, Veerabahu Shanmugasundaram, John Malona, C Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G Hamann, Laure Escoubet, J Michael Ellis
Publié 2021
Accéder au texte intégralPublié 2021
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