CD271 defines a stem cell-like population in hypopharyngeal cancer.
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capab...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c77e94ee6931454bbe14da98b8252b9c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c77e94ee6931454bbe14da98b8252b9c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c77e94ee6931454bbe14da98b8252b9c2021-11-18T07:48:21ZCD271 defines a stem cell-like population in hypopharyngeal cancer.1932-620310.1371/journal.pone.0062002https://doaj.org/article/c77e94ee6931454bbe14da98b8252b9c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23626764/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271(+) cells contained both CD271(+) and CD271(-) cells, indicating that the population could undergo differentiation. Immunohistological analyses of the tumors revealed that the CD271(+) cells localized to a perivascular niche near CD34(+) vasculature, to invasive fronts, and to the basal layer. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271(+) compared to the CD271 (-) cell population. Furthermore, using primary HPC specimens, we demonstrated that high CD271 expression was correlated with a poor prognosis for patients. Taken together, our findings indicate that CD271 is a novel marker for HPC stem-like cells and for HPC prognosis.Takayuki ImaiKeiichi TamaiSayuri OizumiKyoko OyamaKazunori YamaguchiIkuro SatoKennichi SatohKazuto MatsuuraShigeru SaijoKazuo SugamuraNobuyuki TanakaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62002 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Takayuki Imai Keiichi Tamai Sayuri Oizumi Kyoko Oyama Kazunori Yamaguchi Ikuro Sato Kennichi Satoh Kazuto Matsuura Shigeru Saijo Kazuo Sugamura Nobuyuki Tanaka CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| description |
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271(+) cells contained both CD271(+) and CD271(-) cells, indicating that the population could undergo differentiation. Immunohistological analyses of the tumors revealed that the CD271(+) cells localized to a perivascular niche near CD34(+) vasculature, to invasive fronts, and to the basal layer. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271(+) compared to the CD271 (-) cell population. Furthermore, using primary HPC specimens, we demonstrated that high CD271 expression was correlated with a poor prognosis for patients. Taken together, our findings indicate that CD271 is a novel marker for HPC stem-like cells and for HPC prognosis. |
| format |
article |
| author |
Takayuki Imai Keiichi Tamai Sayuri Oizumi Kyoko Oyama Kazunori Yamaguchi Ikuro Sato Kennichi Satoh Kazuto Matsuura Shigeru Saijo Kazuo Sugamura Nobuyuki Tanaka |
| author_facet |
Takayuki Imai Keiichi Tamai Sayuri Oizumi Kyoko Oyama Kazunori Yamaguchi Ikuro Sato Kennichi Satoh Kazuto Matsuura Shigeru Saijo Kazuo Sugamura Nobuyuki Tanaka |
| author_sort |
Takayuki Imai |
| title |
CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| title_short |
CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| title_full |
CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| title_fullStr |
CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| title_full_unstemmed |
CD271 defines a stem cell-like population in hypopharyngeal cancer. |
| title_sort |
cd271 defines a stem cell-like population in hypopharyngeal cancer. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/c77e94ee6931454bbe14da98b8252b9c |
| work_keys_str_mv |
AT takayukiimai cd271definesastemcelllikepopulationinhypopharyngealcancer AT keiichitamai cd271definesastemcelllikepopulationinhypopharyngealcancer AT sayurioizumi cd271definesastemcelllikepopulationinhypopharyngealcancer AT kyokooyama cd271definesastemcelllikepopulationinhypopharyngealcancer AT kazunoriyamaguchi cd271definesastemcelllikepopulationinhypopharyngealcancer AT ikurosato cd271definesastemcelllikepopulationinhypopharyngealcancer AT kennichisatoh cd271definesastemcelllikepopulationinhypopharyngealcancer AT kazutomatsuura cd271definesastemcelllikepopulationinhypopharyngealcancer AT shigerusaijo cd271definesastemcelllikepopulationinhypopharyngealcancer AT kazuosugamura cd271definesastemcelllikepopulationinhypopharyngealcancer AT nobuyukitanaka cd271definesastemcelllikepopulationinhypopharyngealcancer |
| _version_ |
1718422936691408896 |