Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India

Introduction: Chikungunya (CHIK) infection has caused many outbreaks in India with more than 13 lac people affected by the disease. Epidemics of CHIK infection occur during post monsoon period when there is a high vector density. Evidences on the prevalence of CHIK infection during non epidemic...

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Autores principales:	Kaliyamoorthy Kayalvili, Murugan Duraivel, Elangovan Nivedhitha, Subramanian Arul selvan
Formato:	article
Lenguaje:	EN
Publicado:	JCDR Research and Publications Private Limited 2021
Materias:	antibodies enzyme linked immunosorbent assay viral infection Medicine R
Acceso en línea:	https://doaj.org/article/c77f46251d274f2eb1918c5fca9f6051
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spelling	oai:doaj.org-article:c77f46251d274f2eb1918c5fca9f60512021-11-07T08:38:31ZSeroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India10.7860/JCDR/2021/50545.153492249-782X0973-709Xhttps://doaj.org/article/c77f46251d274f2eb1918c5fca9f60512021-09-01T00:00:00Zhttps://www.jcdr.net/articles/PDF/15349/50545_CE[Ra1]_F(SHU)_PF1(AG_SH)_PFA(KM)_PB(AG_KM)_PN(KM).pdfhttps://doaj.org/toc/2249-782Xhttps://doaj.org/toc/0973-709XIntroduction: Chikungunya (CHIK) infection has caused many outbreaks in India with more than 13 lac people affected by the disease. Epidemics of CHIK infection occur during post monsoon period when there is a high vector density. Evidences on the prevalence of CHIK infection during non epidemic periods are limited. Aim: To determine the seroprevalence of CHIK infection during non epidemic periods among patients attending fever clinic in Chennai, Southern India. Materials and Methods: This cross-sectional study was done in 180 suspected cases of CHIK infection between the months of September 2014 and February 2015. A 5 mL of blood samples were collected from the suspected cases and serum was separated to detect for the presence of CHIK-IgM antibody by using CHIK-IgM antibody capture Enzyme Linked Immunosorbent Assay (ELISA) kit. Chi-square test was done to find out the statistical significance with p-value <0.05 kept as statistically significant. Results: The seroprevalence of CHIK infection during non epidemic periods was found to be 5.5% (10/180). Fever and joint pain were the major complaints present in all the study population. All the seronegative cases were tested for the presence of other infections and it was found that 13% were positive for typhoid, 9% were positive for leptospirosis, 4% for malaria and 2% for dengue infections. Conclusion: There are no vaccines or specific medications available till date. Prevention is the only effective approach against the disease. Even though the prevalence of CHIK infection is low during non epidemic periods, strict vector control and elimination of mosquito breeding sites are very important in controlling the disease transmission.Kaliyamoorthy Kayalvili Murugan Duraivel Elangovan NivedhithaSubramanian Arul selvanJCDR Research and Publications Private Limitedarticleantibodiesenzyme linked immunosorbent assayviral infectionMedicineRENJournal of Clinical and Diagnostic Research, Vol 15, Iss 9, Pp DC07-DC10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibodies enzyme linked immunosorbent assay viral infection Medicine R
spellingShingle	antibodies enzyme linked immunosorbent assay viral infection Medicine R Kaliyamoorthy Kayalvili Murugan Duraivel Elangovan Nivedhitha Subramanian Arul selvan Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
description	Introduction: Chikungunya (CHIK) infection has caused many outbreaks in India with more than 13 lac people affected by the disease. Epidemics of CHIK infection occur during post monsoon period when there is a high vector density. Evidences on the prevalence of CHIK infection during non epidemic periods are limited. Aim: To determine the seroprevalence of CHIK infection during non epidemic periods among patients attending fever clinic in Chennai, Southern India. Materials and Methods: This cross-sectional study was done in 180 suspected cases of CHIK infection between the months of September 2014 and February 2015. A 5 mL of blood samples were collected from the suspected cases and serum was separated to detect for the presence of CHIK-IgM antibody by using CHIK-IgM antibody capture Enzyme Linked Immunosorbent Assay (ELISA) kit. Chi-square test was done to find out the statistical significance with p-value <0.05 kept as statistically significant. Results: The seroprevalence of CHIK infection during non epidemic periods was found to be 5.5% (10/180). Fever and joint pain were the major complaints present in all the study population. All the seronegative cases were tested for the presence of other infections and it was found that 13% were positive for typhoid, 9% were positive for leptospirosis, 4% for malaria and 2% for dengue infections. Conclusion: There are no vaccines or specific medications available till date. Prevention is the only effective approach against the disease. Even though the prevalence of CHIK infection is low during non epidemic periods, strict vector control and elimination of mosquito breeding sites are very important in controlling the disease transmission.
format	article
author	Kaliyamoorthy Kayalvili Murugan Duraivel Elangovan Nivedhitha Subramanian Arul selvan
author_facet	Kaliyamoorthy Kayalvili Murugan Duraivel Elangovan Nivedhitha Subramanian Arul selvan
author_sort	Kaliyamoorthy Kayalvili
title	Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
title_short	Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
title_full	Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
title_fullStr	Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
title_full_unstemmed	Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India
title_sort	seroprevalence of chikungunya (chik) infection during non epidemic periods in chennai, southern india
publisher	JCDR Research and Publications Private Limited
publishDate	2021
url	https://doaj.org/article/c77f46251d274f2eb1918c5fca9f6051
work_keys_str_mv	AT kaliyamoorthykayalvili seroprevalenceofchikungunyachikinfectionduringnonepidemicperiodsinchennaisouthernindia AT muruganduraivel seroprevalenceofchikungunyachikinfectionduringnonepidemicperiodsinchennaisouthernindia AT elangovannivedhitha seroprevalenceofchikungunyachikinfectionduringnonepidemicperiodsinchennaisouthernindia AT subramanianarulselvan seroprevalenceofchikungunyachikinfectionduringnonepidemicperiodsinchennaisouthernindia
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Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India

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