Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line

Abstract. Ifandari, Widyarini S, Nugroho LH, Pratiwi R. 2020. Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line. Biodiversitas 21: 1660-1669. Canna indica L is an edible plant with high nutrient conten...

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Autores principales:	IFANDARI, SITARINA WIDYARINI, L. HARTANTO NUGROHO, Rarastoeti Pratiwi
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	canna indica, cytotoxic activity, phytochemical compound Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c78030593b9b48fc8aa5c610b4f7778a
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spelling	oai:doaj.org-article:c78030593b9b48fc8aa5c610b4f7778a2021-11-22T00:34:39ZPhytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line1412-033X2085-472210.13057/biodiv/d210447https://doaj.org/article/c78030593b9b48fc8aa5c610b4f7778a2020-03-01T00:00:00Zhttps://smujo.id/biodiv/article/view/5445https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Ifandari, Widyarini S, Nugroho LH, Pratiwi R. 2020. Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line. Biodiversitas 21: 1660-1669. Canna indica L is an edible plant with high nutrient content and positive health benefits. In Indonesia, edible canna is divided into two cultivar groups: red edible canna and green edible canna. Canna indica L. is investigated in this study as a potential medicinal plant for colon cancer in WiDr cell lines. The phytochemical contents of two distinct cultivars of edible canna (known in Indonesia as ganyong), namely red edible canna and green edible canna. These two discrete samples were extracted by using two different solvents, dichloromethane and ethanol, followed by evaluation using Fourier-transform infrared (FTIR) spectroscopy in order to detected functional group. In the analysis of the composition of the elements of chemical compounds, the samples subsequently injected into the liquid chromatography?high-resolution mass spectrometry (LC-HRMS). The cell viability assay was performed to evaluate the cytotoxic activities of extracted compounds from two cultivars of edible canna in two different solvents. FTIR results demonstrated that the red and green edible canna extracts contained 17 and 18 functional group compounds, respectively. Furthermore, the cell viability was lower in WiDr cells treated with dichloromethane extract of red than green edible canna or the ethanol extract of red edible canna. Notably, LC-HRMS results of the most potent dichloromethane extract of red edible canna revealed the presence of fatty acid compounds. These findings indicate that the two cultivars of edible canna could potentially be utilized as promising candidates for colon cancer treatment.IFANDARISITARINA WIDYARINIL. HARTANTO NUGROHORarastoeti PratiwiMBI & UNS Soloarticlecanna indica, cytotoxic activity, phytochemical compoundBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	canna indica, cytotoxic activity, phytochemical compound Biology (General) QH301-705.5
spellingShingle	canna indica, cytotoxic activity, phytochemical compound Biology (General) QH301-705.5 IFANDARI SITARINA WIDYARINI L. HARTANTO NUGROHO Rarastoeti Pratiwi Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
description	Abstract. Ifandari, Widyarini S, Nugroho LH, Pratiwi R. 2020. Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line. Biodiversitas 21: 1660-1669. Canna indica L is an edible plant with high nutrient content and positive health benefits. In Indonesia, edible canna is divided into two cultivar groups: red edible canna and green edible canna. Canna indica L. is investigated in this study as a potential medicinal plant for colon cancer in WiDr cell lines. The phytochemical contents of two distinct cultivars of edible canna (known in Indonesia as ganyong), namely red edible canna and green edible canna. These two discrete samples were extracted by using two different solvents, dichloromethane and ethanol, followed by evaluation using Fourier-transform infrared (FTIR) spectroscopy in order to detected functional group. In the analysis of the composition of the elements of chemical compounds, the samples subsequently injected into the liquid chromatography?high-resolution mass spectrometry (LC-HRMS). The cell viability assay was performed to evaluate the cytotoxic activities of extracted compounds from two cultivars of edible canna in two different solvents. FTIR results demonstrated that the red and green edible canna extracts contained 17 and 18 functional group compounds, respectively. Furthermore, the cell viability was lower in WiDr cells treated with dichloromethane extract of red than green edible canna or the ethanol extract of red edible canna. Notably, LC-HRMS results of the most potent dichloromethane extract of red edible canna revealed the presence of fatty acid compounds. These findings indicate that the two cultivars of edible canna could potentially be utilized as promising candidates for colon cancer treatment.
format	article
author	IFANDARI SITARINA WIDYARINI L. HARTANTO NUGROHO Rarastoeti Pratiwi
author_facet	IFANDARI SITARINA WIDYARINI L. HARTANTO NUGROHO Rarastoeti Pratiwi
author_sort	IFANDARI
title	Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
title_short	Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
title_full	Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
title_fullStr	Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
title_full_unstemmed	Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line
title_sort	phytochemical analysis and cytotoxic activities of two distinct cultivars of ganyong rhizomes (canna indica) against the widr colon cancer cell line
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/c78030593b9b48fc8aa5c610b4f7778a
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Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line

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