Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-204, which targets Sirt1 in the endothelium to impai...

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Auteurs principaux:	Ajit Vikram, Young-Rae Kim, Santosh Kumar, Qiuxia Li, Modar Kassan, Julia S. Jacobs, Kaikobad Irani
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c78103dbf37e4cb9a31d886ce4bad07c
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spelling	oai:doaj.org-article:c78103dbf37e4cb9a31d886ce4bad07c2021-12-02T16:56:47ZVascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin110.1038/ncomms125652041-1723https://doaj.org/article/c78103dbf37e4cb9a31d886ce4bad07c2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12565https://doaj.org/toc/2041-1723Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-204, which targets Sirt1 in the endothelium to impair endothelial function.Ajit VikramYoung-Rae KimSantosh KumarQiuxia LiModar KassanJulia S. JacobsKaikobad IraniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ajit Vikram Young-Rae Kim Santosh Kumar Qiuxia Li Modar Kassan Julia S. Jacobs Kaikobad Irani Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
description	Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-204, which targets Sirt1 in the endothelium to impair endothelial function.
format	article
author	Ajit Vikram Young-Rae Kim Santosh Kumar Qiuxia Li Modar Kassan Julia S. Jacobs Kaikobad Irani
author_facet	Ajit Vikram Young-Rae Kim Santosh Kumar Qiuxia Li Modar Kassan Julia S. Jacobs Kaikobad Irani
author_sort	Ajit Vikram
title	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
title_short	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
title_full	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
title_fullStr	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
title_full_unstemmed	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
title_sort	vascular microrna-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating sirtuin1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c78103dbf37e4cb9a31d886ce4bad07c
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Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

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