Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study

Background: This study was conducted to demonstrate the effectiveness and safety of herbal medicine and acupuncture treatment in unexplained infertile females. Methods: One hundred patients were recruited from 3 Korean Medicine hospitals in Korea and they voluntarily signed informed consent agreemen...

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Autores principales:	Su-Ji Choi, Dong-Il Kim, Sang Ho Yoon, Chi-Yeon Lim, Jin-Moo Lee, Chang-Min Choe
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Acupuncture Korean medicine Herbal medicine Infertility Pregnancy rate Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/c78299c7fb754aa585a898f49c760a61
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spelling	oai:doaj.org-article:c78299c7fb754aa585a898f49c760a612021-11-28T04:31:36ZEffectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study2213-422010.1016/j.imr.2021.100751https://doaj.org/article/c78299c7fb754aa585a898f49c760a612021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221342202100038Xhttps://doaj.org/toc/2213-4220Background: This study was conducted to demonstrate the effectiveness and safety of herbal medicine and acupuncture treatment in unexplained infertile females. Methods: One hundred patients were recruited from 3 Korean Medicine hospitals in Korea and they voluntarily signed informed consent agreements. Participants took the Onkyeong-tang (120cc) twice daily between menstrual cycle day (MCD) 3 and 12, and herbal medicine for ovulation and implantation (120cc) twice daily between MCD 13 and 28. They also received acupuncture and moxibustion treatment during 4 menstrual cycles. After the 4 menstrual cycle treatment period, there were 3 menstrual cycle observation periods. The primary outcome is signified by clinical pregnancy rates (CPR) and the secondary outcomes were implantation rates (IR), ongoing pregnancy rates (OPR), and live birth rates. Results: 90 patients completed the study. 13 of the 90 subjects became pregnant. The CPR and IR was 14.44%. 7 of 13 pregnant subjects had continuing pregnancy for over 12 weeks, so that the OPR was 53.85%. The birth rate was 7.78%. All 7 pregnant patients gave birth to their babies and all the babies were live singletons and healthy. There were no serious adverse events. Conclusions: The findings of this study may provide the possibility of effectiveness and safety of Korea medicine treatment for unexplained infertile women. Further study is required due to lack of control and small sample size in this study.Su-Ji ChoiDong-Il KimSang Ho YoonChi-Yeon LimJin-Moo LeeChang-Min ChoeElsevierarticleAcupunctureKorean medicineHerbal medicineInfertilityPregnancy rateMiscellaneous systems and treatmentsRZ409.7-999ENIntegrative Medicine Research, Vol 10, Iss 4, Pp 100751- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acupuncture Korean medicine Herbal medicine Infertility Pregnancy rate Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Acupuncture Korean medicine Herbal medicine Infertility Pregnancy rate Miscellaneous systems and treatments RZ409.7-999 Su-Ji Choi Dong-Il Kim Sang Ho Yoon Chi-Yeon Lim Jin-Moo Lee Chang-Min Choe Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
description	Background: This study was conducted to demonstrate the effectiveness and safety of herbal medicine and acupuncture treatment in unexplained infertile females. Methods: One hundred patients were recruited from 3 Korean Medicine hospitals in Korea and they voluntarily signed informed consent agreements. Participants took the Onkyeong-tang (120cc) twice daily between menstrual cycle day (MCD) 3 and 12, and herbal medicine for ovulation and implantation (120cc) twice daily between MCD 13 and 28. They also received acupuncture and moxibustion treatment during 4 menstrual cycles. After the 4 menstrual cycle treatment period, there were 3 menstrual cycle observation periods. The primary outcome is signified by clinical pregnancy rates (CPR) and the secondary outcomes were implantation rates (IR), ongoing pregnancy rates (OPR), and live birth rates. Results: 90 patients completed the study. 13 of the 90 subjects became pregnant. The CPR and IR was 14.44%. 7 of 13 pregnant subjects had continuing pregnancy for over 12 weeks, so that the OPR was 53.85%. The birth rate was 7.78%. All 7 pregnant patients gave birth to their babies and all the babies were live singletons and healthy. There were no serious adverse events. Conclusions: The findings of this study may provide the possibility of effectiveness and safety of Korea medicine treatment for unexplained infertile women. Further study is required due to lack of control and small sample size in this study.
format	article
author	Su-Ji Choi Dong-Il Kim Sang Ho Yoon Chi-Yeon Lim Jin-Moo Lee Chang-Min Choe
author_facet	Su-Ji Choi Dong-Il Kim Sang Ho Yoon Chi-Yeon Lim Jin-Moo Lee Chang-Min Choe
author_sort	Su-Ji Choi
title	Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
title_short	Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
title_full	Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
title_fullStr	Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
title_full_unstemmed	Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study
title_sort	effectiveness and safety of korean medicine for treating women with unexplained infertility: a multi-center observational study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c78299c7fb754aa585a898f49c760a61
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Effectiveness and safety of Korean medicine for treating women with unexplained infertility: A multi-center observational study

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