Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.

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Autores principales:	Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Tatiana Nikitina, Victor B. Zhurkin, Polly Fordyce, Timothy J. Stasevich, Howard Y. Chang, William J. Greenleaf, Jan T. Liphardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c785b7867538444e850f8a448f988344
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spelling	oai:doaj.org-article:c785b7867538444e850f8a448f9883442021-12-02T17:31:21ZSatb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions10.1038/s41467-019-11118-82041-1723https://doaj.org/article/c785b7867538444e850f8a448f9883442019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11118-8https://doaj.org/toc/2041-1723Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.Rajarshi P. GhoshQuanming ShiLinfeng YangMichael P. ReddickTatiana NikitinaVictor B. ZhurkinPolly FordyceTimothy J. StasevichHoward Y. ChangWilliam J. GreenleafJan T. LiphardtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajarshi P. Ghosh Quanming Shi Linfeng Yang Michael P. Reddick Tatiana Nikitina Victor B. Zhurkin Polly Fordyce Timothy J. Stasevich Howard Y. Chang William J. Greenleaf Jan T. Liphardt Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
description	Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.
format	article
author	Rajarshi P. Ghosh Quanming Shi Linfeng Yang Michael P. Reddick Tatiana Nikitina Victor B. Zhurkin Polly Fordyce Timothy J. Stasevich Howard Y. Chang William J. Greenleaf Jan T. Liphardt
author_facet	Rajarshi P. Ghosh Quanming Shi Linfeng Yang Michael P. Reddick Tatiana Nikitina Victor B. Zhurkin Polly Fordyce Timothy J. Stasevich Howard Y. Chang William J. Greenleaf Jan T. Liphardt
author_sort	Rajarshi P. Ghosh
title	Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
title_short	Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
title_full	Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
title_fullStr	Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
title_full_unstemmed	Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
title_sort	satb1 integrates dna binding site geometry and torsional stress to differentially target nucleosome-dense regions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c785b7867538444e850f8a448f988344
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Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

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