Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.

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Detalles Bibliográficos
Autores principales: Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Tatiana Nikitina, Victor B. Zhurkin, Polly Fordyce, Timothy J. Stasevich, Howard Y. Chang, William J. Greenleaf, Jan T. Liphardt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c785b7867538444e850f8a448f988344
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