Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells
Summary: HIV-1 infects blood CD4 T cells through the use of CD4 and CXCR4 or CCR5 receptors, which can be targeted through blocking viral binding to CD4/CXCR4/CCR5 or virus-cell fusion. Here we describe a novel mechanism by which HIV-1 nuclear entry can also be blocked through targeting a non-entry...
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Elsevier
2021
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oai:doaj.org-article:c78825a51f2d4c4ca0d788a5bcae008a2021-11-20T05:09:42ZPrestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells2589-004210.1016/j.isci.2021.103305https://doaj.org/article/c78825a51f2d4c4ca0d788a5bcae008a2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012748https://doaj.org/toc/2589-0042Summary: HIV-1 infects blood CD4 T cells through the use of CD4 and CXCR4 or CCR5 receptors, which can be targeted through blocking viral binding to CD4/CXCR4/CCR5 or virus-cell fusion. Here we describe a novel mechanism by which HIV-1 nuclear entry can also be blocked through targeting a non-entry receptor, CD2. Cluster of differentiation 2 (CD2) is an adhesion molecule highly expressed on human blood CD4, particularly, memory CD4 T cells. We found that CD2 ligation with its cell-free ligand LFA-3 or anti-CD2 antibodies rendered blood resting CD4 T cells highly resistant to HIV-1 infection. We further demonstrate that mechanistically, CD2 binding initiates competitive signaling leading to cofilin activation and localized actin polymerization around CD2, which spatially inhibits HIV-1-initiated local actin polymerization needed for viral nuclear migration. Our study identifies CD2 as a novel target to block HIV-1 infection of blood resting T cells.Sijia HeJia GuoYajing FuMark SpearChaolong QinShuai FuZongqiang CuiWenwen JinXuehua XuWanjun ChenHong ShangYuntao WuElsevierarticleImmune responseImmunologyVirologyScienceQENiScience, Vol 24, Iss 11, Pp 103305- (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Immune response Immunology Virology Science Q |
| spellingShingle |
Immune response Immunology Virology Science Q Sijia He Jia Guo Yajing Fu Mark Spear Chaolong Qin Shuai Fu Zongqiang Cui Wenwen Jin Xuehua Xu Wanjun Chen Hong Shang Yuntao Wu Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| description |
Summary: HIV-1 infects blood CD4 T cells through the use of CD4 and CXCR4 or CCR5 receptors, which can be targeted through blocking viral binding to CD4/CXCR4/CCR5 or virus-cell fusion. Here we describe a novel mechanism by which HIV-1 nuclear entry can also be blocked through targeting a non-entry receptor, CD2. Cluster of differentiation 2 (CD2) is an adhesion molecule highly expressed on human blood CD4, particularly, memory CD4 T cells. We found that CD2 ligation with its cell-free ligand LFA-3 or anti-CD2 antibodies rendered blood resting CD4 T cells highly resistant to HIV-1 infection. We further demonstrate that mechanistically, CD2 binding initiates competitive signaling leading to cofilin activation and localized actin polymerization around CD2, which spatially inhibits HIV-1-initiated local actin polymerization needed for viral nuclear migration. Our study identifies CD2 as a novel target to block HIV-1 infection of blood resting T cells. |
| format |
article |
| author |
Sijia He Jia Guo Yajing Fu Mark Spear Chaolong Qin Shuai Fu Zongqiang Cui Wenwen Jin Xuehua Xu Wanjun Chen Hong Shang Yuntao Wu |
| author_facet |
Sijia He Jia Guo Yajing Fu Mark Spear Chaolong Qin Shuai Fu Zongqiang Cui Wenwen Jin Xuehua Xu Wanjun Chen Hong Shang Yuntao Wu |
| author_sort |
Sijia He |
| title |
Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| title_short |
Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| title_full |
Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| title_fullStr |
Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| title_full_unstemmed |
Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells |
| title_sort |
prestimulation of cd2 confers resistance to hiv-1 latent infection in blood resting cd4 t cells |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/c78825a51f2d4c4ca0d788a5bcae008a |
| work_keys_str_mv |
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| _version_ |
1718419566364721152 |