Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells

Summary: HIV-1 infects blood CD4 T cells through the use of CD4 and CXCR4 or CCR5 receptors, which can be targeted through blocking viral binding to CD4/CXCR4/CCR5 or virus-cell fusion. Here we describe a novel mechanism by which HIV-1 nuclear entry can also be blocked through targeting a non-entry...

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Autores principales: Sijia He, Jia Guo, Yajing Fu, Mark Spear, Chaolong Qin, Shuai Fu, Zongqiang Cui, Wenwen Jin, Xuehua Xu, Wanjun Chen, Hong Shang, Yuntao Wu
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/c78825a51f2d4c4ca0d788a5bcae008a
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