6mer seed toxicity in tumor suppressive microRNAs

Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.

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Detalles Bibliográficos
Autores principales:	Quan Q. Gao, William E. Putzbach, Andrea E. Murmann, Siquan Chen, Aishe A. Sarshad, Johannes M. Peter, Elizabeth T. Bartom, Markus Hafner, Marcus E. Peter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c78972507df3463e9a2616f3688e2bbe
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spelling	oai:doaj.org-article:c78972507df3463e9a2616f3688e2bbe2021-12-02T16:49:40Z6mer seed toxicity in tumor suppressive microRNAs10.1038/s41467-018-06526-12041-1723https://doaj.org/article/c78972507df3463e9a2616f3688e2bbe2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06526-1https://doaj.org/toc/2041-1723Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.Quan Q. GaoWilliam E. PutzbachAndrea E. MurmannSiquan ChenAishe A. SarshadJohannes M. PeterElizabeth T. BartomMarkus HafnerMarcus E. PeterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quan Q. Gao William E. Putzbach Andrea E. Murmann Siquan Chen Aishe A. Sarshad Johannes M. Peter Elizabeth T. Bartom Markus Hafner Marcus E. Peter 6mer seed toxicity in tumor suppressive microRNAs
description	Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.
format	article
author	Quan Q. Gao William E. Putzbach Andrea E. Murmann Siquan Chen Aishe A. Sarshad Johannes M. Peter Elizabeth T. Bartom Markus Hafner Marcus E. Peter
author_facet	Quan Q. Gao William E. Putzbach Andrea E. Murmann Siquan Chen Aishe A. Sarshad Johannes M. Peter Elizabeth T. Bartom Markus Hafner Marcus E. Peter
author_sort	Quan Q. Gao
title	6mer seed toxicity in tumor suppressive microRNAs
title_short	6mer seed toxicity in tumor suppressive microRNAs
title_full	6mer seed toxicity in tumor suppressive microRNAs
title_fullStr	6mer seed toxicity in tumor suppressive microRNAs
title_full_unstemmed	6mer seed toxicity in tumor suppressive microRNAs
title_sort	6mer seed toxicity in tumor suppressive micrornas
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c78972507df3463e9a2616f3688e2bbe
work_keys_str_mv	AT quanqgao 6merseedtoxicityintumorsuppressivemicrornas AT williameputzbach 6merseedtoxicityintumorsuppressivemicrornas AT andreaemurmann 6merseedtoxicityintumorsuppressivemicrornas AT siquanchen 6merseedtoxicityintumorsuppressivemicrornas AT aisheasarshad 6merseedtoxicityintumorsuppressivemicrornas AT johannesmpeter 6merseedtoxicityintumorsuppressivemicrornas AT elizabethtbartom 6merseedtoxicityintumorsuppressivemicrornas AT markushafner 6merseedtoxicityintumorsuppressivemicrornas AT marcusepeter 6merseedtoxicityintumorsuppressivemicrornas
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6mer seed toxicity in tumor suppressive microRNAs

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