Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the u...

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Autores principales:	M. S. Panova, A. S. Panchenko, V. A. Mudrov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	hypoxic damage brain hypoxia asphyxia cytokines interleukins neuron-specific enolase Science Q
Acceso en línea:	https://doaj.org/article/c78c9eea75bf49a4ab818882475c4d6f
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spelling	oai:doaj.org-article:c78c9eea75bf49a4ab818882475c4d6f2021-11-23T06:14:46ZOptimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns2541-94202587-959610.29413/ABS.2021-6.2.15https://doaj.org/article/c78c9eea75bf49a4ab818882475c4d6f2021-06-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2744https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period.M. S. PanovaA. S. PanchenkoV. A. MudrovScientific Сentre for Family Health and Human Reproduction Problemsarticlehypoxic damagebrainhypoxiaasphyxiacytokinesinterleukinsneuron-specific enolaseScienceQRUActa Biomedica Scientifica, Vol 6, Iss 2, Pp 133-141 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	hypoxic damage brain hypoxia asphyxia cytokines interleukins neuron-specific enolase Science Q
spellingShingle	hypoxic damage brain hypoxia asphyxia cytokines interleukins neuron-specific enolase Science Q M. S. Panova A. S. Panchenko V. A. Mudrov Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
description	The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period.
format	article
author	M. S. Panova A. S. Panchenko V. A. Mudrov
author_facet	M. S. Panova A. S. Panchenko V. A. Mudrov
author_sort	M. S. Panova
title	Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
title_short	Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
title_full	Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
title_fullStr	Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
title_full_unstemmed	Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns
title_sort	optimization of hypoxic brain injuries diagnostics in full-term newborns
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/c78c9eea75bf49a4ab818882475c4d6f
work_keys_str_mv	AT mspanova optimizationofhypoxicbraininjuriesdiagnosticsinfulltermnewborns AT aspanchenko optimizationofhypoxicbraininjuriesdiagnosticsinfulltermnewborns AT vamudrov optimizationofhypoxicbraininjuriesdiagnosticsinfulltermnewborns
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Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

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