Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs

The chemical composition of Lebanese <i>Hypericum scabrum</i> essential oil (EO) was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GG-MS). Its antimicrobial activity was evaluated by determining its minimal inhibitory concentrations (MICs) against a Gram-n...

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Autores principales:	Layal Fahed, Marc El Beyrouthy, Naïm Ouaini, Véronique Eparvier, Didier Stien, Sara Vitalini, Marcello Iriti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Hypericum scabrum</i> essential oil chemical composition antimicrobial activity synergy Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c79262c6e8df49a3827ffd7e176889a6
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spelling	oai:doaj.org-article:c79262c6e8df49a3827ffd7e176889a62021-11-11T18:31:49ZAntimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs10.3390/molecules262165451420-3049https://doaj.org/article/c79262c6e8df49a3827ffd7e176889a62021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6545https://doaj.org/toc/1420-3049The chemical composition of Lebanese <i>Hypericum scabrum</i> essential oil (EO) was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GG-MS). Its antimicrobial activity was evaluated by determining its minimal inhibitory concentrations (MICs) against a Gram-negative and a Gram-positive bacterium, one yeast, and five dermatophytes. <i>H. scabrum</i> EO was most active on filamentous fungi (MIC values of 32–64 µg/mL). Synergy within the oil was investigated by testing each of the following major components on <i>Trichophyton rubrum</i>: <i>α</i>-pinene, limonene, myrcene, <i>β</i>-pinene and nonane, as well as a reconstructed EO. The antifungal activity of the natural oil could not be reached, meaning that its activity might be due, in part, to minor constituent(s). The interactions between <i>H. scabrum</i> EO and commercially available antifungals were assessed by the checkerboard test. A synergistic effect was revealed in the combination of the EO with amphotericin B.Layal FahedMarc El BeyrouthyNaïm OuainiVéronique EparvierDidier StienSara VitaliniMarcello IritiMDPI AGarticle<i>Hypericum scabrum</i>essential oilchemical compositionantimicrobial activitysynergyOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6545, p 6545 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Hypericum scabrum</i> essential oil chemical composition antimicrobial activity synergy Organic chemistry QD241-441
spellingShingle	<i>Hypericum scabrum</i> essential oil chemical composition antimicrobial activity synergy Organic chemistry QD241-441 Layal Fahed Marc El Beyrouthy Naïm Ouaini Véronique Eparvier Didier Stien Sara Vitalini Marcello Iriti Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
description	The chemical composition of Lebanese <i>Hypericum scabrum</i> essential oil (EO) was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GG-MS). Its antimicrobial activity was evaluated by determining its minimal inhibitory concentrations (MICs) against a Gram-negative and a Gram-positive bacterium, one yeast, and five dermatophytes. <i>H. scabrum</i> EO was most active on filamentous fungi (MIC values of 32–64 µg/mL). Synergy within the oil was investigated by testing each of the following major components on <i>Trichophyton rubrum</i>: <i>α</i>-pinene, limonene, myrcene, <i>β</i>-pinene and nonane, as well as a reconstructed EO. The antifungal activity of the natural oil could not be reached, meaning that its activity might be due, in part, to minor constituent(s). The interactions between <i>H. scabrum</i> EO and commercially available antifungals were assessed by the checkerboard test. A synergistic effect was revealed in the combination of the EO with amphotericin B.
format	article
author	Layal Fahed Marc El Beyrouthy Naïm Ouaini Véronique Eparvier Didier Stien Sara Vitalini Marcello Iriti
author_facet	Layal Fahed Marc El Beyrouthy Naïm Ouaini Véronique Eparvier Didier Stien Sara Vitalini Marcello Iriti
author_sort	Layal Fahed
title	Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
title_short	Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
title_full	Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
title_fullStr	Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
title_full_unstemmed	Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs
title_sort	antimicrobial activity and synergy investigation of <i>hypericum scabrum</i> essential oil with antifungal drugs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c79262c6e8df49a3827ffd7e176889a6
work_keys_str_mv	AT layalfahed antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT marcelbeyrouthy antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT naimouaini antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT veroniqueeparvier antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT didierstien antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT saravitalini antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs AT marcelloiriti antimicrobialactivityandsynergyinvestigationofihypericumscabrumiessentialoilwithantifungaldrugs
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Antimicrobial Activity and Synergy Investigation of <i>Hypericum scabrum</i> Essential Oil with Antifungal Drugs

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