Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1

The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope. Here the authors present the crystal structure of human MAJIN-TERB2 and combine biophysical approaches and structured illumination microscopy analysis of mouse meiotic chromosomes to characterize the mo...

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Autores principales: James M. Dunce, Amy E. Milburn, Manickam Gurusaran, Irene da Cruz, Lee T. Sen, Ricardo Benavente, Owen R. Davies
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c795be0929864372986ddb798eaeecbf
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Sumario:The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope. Here the authors present the crystal structure of human MAJIN-TERB2 and combine biophysical approaches and structured illumination microscopy analysis of mouse meiotic chromosomes to characterize the molecular architecture of the wider MAJIN-TERB2-TERB1 complex and its interactions with TRF1.