Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols

Introduction. Keratoconus is a progressive corneal disease commonly treated by collagen cross-linking (CXL). Accelerated protocols have recently become common. This study sought to compare the outcomes of accelerated and standard CXL in terms of visual acuity, keratometry, and tomographic parameters...

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Autores principales:	Shira Hed, Ran Matlov Kormas, Sagi Shashar, Boris E. Malyugin, Matthew Boyko, Boris Knyazer
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c7996f9f79014f0bb276811f3bb6795c
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spelling	oai:doaj.org-article:c7996f9f79014f0bb276811f3bb6795c2021-11-15T01:19:49ZCorneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols2090-005810.1155/2021/2659828https://doaj.org/article/c7996f9f79014f0bb276811f3bb6795c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2659828https://doaj.org/toc/2090-0058Introduction. Keratoconus is a progressive corneal disease commonly treated by collagen cross-linking (CXL). Accelerated protocols have recently become common. This study sought to compare the outcomes of accelerated and standard CXL in terms of visual acuity, keratometry, and tomographic parameters in pediatric population. Methods. We retrospectively reviewed the files of pediatric patients who underwent standard and accelerated CXL for keratoconus in our hospital, between October 2014 and March 2018. Changes in uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), tomographic keratometry parameters (Kmax, Ksteep, Kflat, Kmean), and endothelial density count (EDC) were assessed before and at 6 and 12 months following treatment. The analysis included intergroup and intragroup comparisons. Results. This study included 53 eyes (44 patients). Fourteen eyes were treated with standard CXL (S-CXL, 3 mW/cm2, 30 min), while 39 underwent accelerated CXL (A-CXL, 9 mW/cm2, 10 min). Intergroup comparison found insignificant differences between groups, with the exception of better results for UCDVA in the S-CXL group after 12 months (P = 0.03). In this study, there was no significant difference between the two protocols postoperatively in BCDVA, Kmax, Kmean, pachymetry, or corneal astigmatism. Conclusion. A-CXL is as safe and effective as S-CXL for stabilizing progressive keratoconus in pediatric population. Larger-sample-size studies with a longer follow-up time are required. Considering the long-term results of 9 mW A-CXL and its safety and efficacy profile, it should be preferred to S-CXL for reducing treatment time and improving patients’ comfort.Shira HedRan Matlov KormasSagi ShasharBoris E. MalyuginMatthew BoykoBoris KnyazerHindawi LimitedarticleOphthalmologyRE1-994ENJournal of Ophthalmology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Shira Hed Ran Matlov Kormas Sagi Shashar Boris E. Malyugin Matthew Boyko Boris Knyazer Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
description	Introduction. Keratoconus is a progressive corneal disease commonly treated by collagen cross-linking (CXL). Accelerated protocols have recently become common. This study sought to compare the outcomes of accelerated and standard CXL in terms of visual acuity, keratometry, and tomographic parameters in pediatric population. Methods. We retrospectively reviewed the files of pediatric patients who underwent standard and accelerated CXL for keratoconus in our hospital, between October 2014 and March 2018. Changes in uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), tomographic keratometry parameters (Kmax, Ksteep, Kflat, Kmean), and endothelial density count (EDC) were assessed before and at 6 and 12 months following treatment. The analysis included intergroup and intragroup comparisons. Results. This study included 53 eyes (44 patients). Fourteen eyes were treated with standard CXL (S-CXL, 3 mW/cm2, 30 min), while 39 underwent accelerated CXL (A-CXL, 9 mW/cm2, 10 min). Intergroup comparison found insignificant differences between groups, with the exception of better results for UCDVA in the S-CXL group after 12 months (P = 0.03). In this study, there was no significant difference between the two protocols postoperatively in BCDVA, Kmax, Kmean, pachymetry, or corneal astigmatism. Conclusion. A-CXL is as safe and effective as S-CXL for stabilizing progressive keratoconus in pediatric population. Larger-sample-size studies with a longer follow-up time are required. Considering the long-term results of 9 mW A-CXL and its safety and efficacy profile, it should be preferred to S-CXL for reducing treatment time and improving patients’ comfort.
format	article
author	Shira Hed Ran Matlov Kormas Sagi Shashar Boris E. Malyugin Matthew Boyko Boris Knyazer
author_facet	Shira Hed Ran Matlov Kormas Sagi Shashar Boris E. Malyugin Matthew Boyko Boris Knyazer
author_sort	Shira Hed
title	Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
title_short	Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
title_full	Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
title_fullStr	Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
title_full_unstemmed	Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols
title_sort	corneal cross-linking as treatment in pediatric keratoconus: comparison of two protocols
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c7996f9f79014f0bb276811f3bb6795c
work_keys_str_mv	AT shirahed cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols AT ranmatlovkormas cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols AT sagishashar cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols AT borisemalyugin cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols AT matthewboyko cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols AT borisknyazer cornealcrosslinkingastreatmentinpediatrickeratoconuscomparisonoftwoprotocols
_version_	1718428948257308672

Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols

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