Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduct...

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Autores principales:	Sara M. Willems, Daniel J. Wright, Felix R. Day, Katerina Trajanoska, Peter K. Joshi, John A. Morris, Amy M. Matteini, Fleur C. Garton, Niels Grarup, Nikolay Oskolkov, Anbupalam Thalamuthu, Massimo Mangino, Jun Liu, Ayse Demirkan, Monkol Lek, Liwen Xu, Guan Wang, Christopher Oldmeadow, Kyle J. Gaulton, Luca A. Lotta, Eri Miyamoto-Mikami, Manuel A. Rivas, Tom White, Po-Ru Loh, Mette Aadahl, Najaf Amin, John R. Attia, Krista Austin, Beben Benyamin, Søren Brage, Yu-Ching Cheng, Paweł Cięszczyk, Wim Derave, Karl-Fredrik Eriksson, Nir Eynon, Allan Linneberg, Alejandro Lucia, Myosotis Massidda, Braxton D. Mitchell, Motohiko Miyachi, Haruka Murakami, Sandosh Padmanabhan, Ashutosh Pandey, Ioannis Papadimitriou, Deepak K. Rajpal, Craig Sale, Theresia M. Schnurr, Francesco Sessa, Nick Shrine, Martin D. Tobin, Ian Varley, Louise V. Wain, Naomi R. Wray, Cecilia M. Lindgren, Daniel G. MacArthur, Dawn M. Waterworth, Mark I. McCarthy, Oluf Pedersen, Kay-Tee Khaw, Douglas P. Kiel, GEFOS Any-Type of Fracture Consortium, Yannis Pitsiladis, Noriyuki Fuku, Paul W. Franks, Kathryn N. North, Cornelia M. van Duijn, Karen A. Mather, Torben Hansen, Ola Hansson, Tim Spector, Joanne M. Murabito, J. Brent Richards, Fernando Rivadeneira, Claudia Langenberg, John R. B. Perry, Nick J. Wareham, Robert A. Scott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c79d45da5079409b8be2da8ab36a65af
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spelling	oai:doaj.org-article:c79d45da5079409b8be2da8ab36a65af2021-12-02T17:01:23ZLarge-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness10.1038/ncomms160152041-1723https://doaj.org/article/c79d45da5079409b8be2da8ab36a65af2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16015https://doaj.org/toc/2041-1723Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.Sara M. WillemsDaniel J. WrightFelix R. DayKaterina TrajanoskaPeter K. JoshiJohn A. MorrisAmy M. MatteiniFleur C. GartonNiels GrarupNikolay OskolkovAnbupalam ThalamuthuMassimo ManginoJun LiuAyse DemirkanMonkol LekLiwen XuGuan WangChristopher OldmeadowKyle J. GaultonLuca A. LottaEri Miyamoto-MikamiManuel A. RivasTom WhitePo-Ru LohMette AadahlNajaf AminJohn R. AttiaKrista AustinBeben BenyaminSøren BrageYu-Ching ChengPaweł CięszczykWim DeraveKarl-Fredrik ErikssonNir EynonAllan LinnebergAlejandro LuciaMyosotis MassiddaBraxton D. MitchellMotohiko MiyachiHaruka MurakamiSandosh PadmanabhanAshutosh PandeyIoannis PapadimitriouDeepak K. RajpalCraig SaleTheresia M. SchnurrFrancesco SessaNick ShrineMartin D. TobinIan VarleyLouise V. WainNaomi R. WrayCecilia M. LindgrenDaniel G. MacArthurDawn M. WaterworthMark I. McCarthyOluf PedersenKay-Tee KhawDouglas P. KielGEFOS Any-Type of Fracture ConsortiumYannis PitsiladisNoriyuki FukuPaul W. FranksKathryn N. NorthCornelia M. van DuijnKaren A. MatherTorben HansenOla HanssonTim SpectorJoanne M. MurabitoJ. Brent RichardsFernando RivadeneiraClaudia LangenbergJohn R. B. PerryNick J. WarehamRobert A. ScottNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara M. Willems Daniel J. Wright Felix R. Day Katerina Trajanoska Peter K. Joshi John A. Morris Amy M. Matteini Fleur C. Garton Niels Grarup Nikolay Oskolkov Anbupalam Thalamuthu Massimo Mangino Jun Liu Ayse Demirkan Monkol Lek Liwen Xu Guan Wang Christopher Oldmeadow Kyle J. Gaulton Luca A. Lotta Eri Miyamoto-Mikami Manuel A. Rivas Tom White Po-Ru Loh Mette Aadahl Najaf Amin John R. Attia Krista Austin Beben Benyamin Søren Brage Yu-Ching Cheng Paweł Cięszczyk Wim Derave Karl-Fredrik Eriksson Nir Eynon Allan Linneberg Alejandro Lucia Myosotis Massidda Braxton D. Mitchell Motohiko Miyachi Haruka Murakami Sandosh Padmanabhan Ashutosh Pandey Ioannis Papadimitriou Deepak K. Rajpal Craig Sale Theresia M. Schnurr Francesco Sessa Nick Shrine Martin D. Tobin Ian Varley Louise V. Wain Naomi R. Wray Cecilia M. Lindgren Daniel G. MacArthur Dawn M. Waterworth Mark I. McCarthy Oluf Pedersen Kay-Tee Khaw Douglas P. Kiel GEFOS Any-Type of Fracture Consortium Yannis Pitsiladis Noriyuki Fuku Paul W. Franks Kathryn N. North Cornelia M. van Duijn Karen A. Mather Torben Hansen Ola Hansson Tim Spector Joanne M. Murabito J. Brent Richards Fernando Rivadeneira Claudia Langenberg John R. B. Perry Nick J. Wareham Robert A. Scott Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
description	Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.
format	article
author	Sara M. Willems Daniel J. Wright Felix R. Day Katerina Trajanoska Peter K. Joshi John A. Morris Amy M. Matteini Fleur C. Garton Niels Grarup Nikolay Oskolkov Anbupalam Thalamuthu Massimo Mangino Jun Liu Ayse Demirkan Monkol Lek Liwen Xu Guan Wang Christopher Oldmeadow Kyle J. Gaulton Luca A. Lotta Eri Miyamoto-Mikami Manuel A. Rivas Tom White Po-Ru Loh Mette Aadahl Najaf Amin John R. Attia Krista Austin Beben Benyamin Søren Brage Yu-Ching Cheng Paweł Cięszczyk Wim Derave Karl-Fredrik Eriksson Nir Eynon Allan Linneberg Alejandro Lucia Myosotis Massidda Braxton D. Mitchell Motohiko Miyachi Haruka Murakami Sandosh Padmanabhan Ashutosh Pandey Ioannis Papadimitriou Deepak K. Rajpal Craig Sale Theresia M. Schnurr Francesco Sessa Nick Shrine Martin D. Tobin Ian Varley Louise V. Wain Naomi R. Wray Cecilia M. Lindgren Daniel G. MacArthur Dawn M. Waterworth Mark I. McCarthy Oluf Pedersen Kay-Tee Khaw Douglas P. Kiel GEFOS Any-Type of Fracture Consortium Yannis Pitsiladis Noriyuki Fuku Paul W. Franks Kathryn N. North Cornelia M. van Duijn Karen A. Mather Torben Hansen Ola Hansson Tim Spector Joanne M. Murabito J. Brent Richards Fernando Rivadeneira Claudia Langenberg John R. B. Perry Nick J. Wareham Robert A. Scott
author_facet	Sara M. Willems Daniel J. Wright Felix R. Day Katerina Trajanoska Peter K. Joshi John A. Morris Amy M. Matteini Fleur C. Garton Niels Grarup Nikolay Oskolkov Anbupalam Thalamuthu Massimo Mangino Jun Liu Ayse Demirkan Monkol Lek Liwen Xu Guan Wang Christopher Oldmeadow Kyle J. Gaulton Luca A. Lotta Eri Miyamoto-Mikami Manuel A. Rivas Tom White Po-Ru Loh Mette Aadahl Najaf Amin John R. Attia Krista Austin Beben Benyamin Søren Brage Yu-Ching Cheng Paweł Cięszczyk Wim Derave Karl-Fredrik Eriksson Nir Eynon Allan Linneberg Alejandro Lucia Myosotis Massidda Braxton D. Mitchell Motohiko Miyachi Haruka Murakami Sandosh Padmanabhan Ashutosh Pandey Ioannis Papadimitriou Deepak K. Rajpal Craig Sale Theresia M. Schnurr Francesco Sessa Nick Shrine Martin D. Tobin Ian Varley Louise V. Wain Naomi R. Wray Cecilia M. Lindgren Daniel G. MacArthur Dawn M. Waterworth Mark I. McCarthy Oluf Pedersen Kay-Tee Khaw Douglas P. Kiel GEFOS Any-Type of Fracture Consortium Yannis Pitsiladis Noriyuki Fuku Paul W. Franks Kathryn N. North Cornelia M. van Duijn Karen A. Mather Torben Hansen Ola Hansson Tim Spector Joanne M. Murabito J. Brent Richards Fernando Rivadeneira Claudia Langenberg John R. B. Perry Nick J. Wareham Robert A. Scott
author_sort	Sara M. Willems
title	Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
title_short	Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
title_full	Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
title_fullStr	Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
title_full_unstemmed	Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
title_sort	large-scale gwas identifies multiple loci for hand grip strength providing biological insights into muscular fitness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c79d45da5079409b8be2da8ab36a65af
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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

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