Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver

Abstract To investigate the effects of PEG-coated gold nanoparticles on ablation zone volumes following in vivo radiofrequency ablation of porcine liver. This prospective study was performed following institutional animal care and committee approval was used. Radiofrequency ablations were performed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tudor Mocan, Rares Stiufiuc, Calin Popa, Iuliana Nenu, Cosmin Pestean, Andras Laszlo Nagy, Lavinia Patricia Mocan, Daniel Corneliu Leucuta, Nadim Al Hajjar, Zeno Sparchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c79f64d15cdb4a5a80e0f3883aacbe08
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c79f64d15cdb4a5a80e0f3883aacbe08
record_format	dspace
spelling	oai:doaj.org-article:c79f64d15cdb4a5a80e0f3883aacbe082021-12-02T14:12:45ZPercutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver10.1038/s41598-020-79917-42045-2322https://doaj.org/article/c79f64d15cdb4a5a80e0f3883aacbe082021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79917-4https://doaj.org/toc/2045-2322Abstract To investigate the effects of PEG-coated gold nanoparticles on ablation zone volumes following in vivo radiofrequency ablation of porcine liver. This prospective study was performed following institutional animal care and committee approval was used. Radiofrequency ablations were performed in the livers of ten Sus scrofa domesticus swines. During each ablation, 10 mL (mL) of Peg-coated gold nanoparticles at two different concentrations (0.5 mg/mL and 0.01 mg/mL) were injected through the electrode channel into the target zone. For the control group, 10 mL of physiological saline was used. Five to ten minutes after each ablation, contrast enhanced ultrasound (CEUS) was performed to evaluate the volume of the coagulation zone. On day five we performed another CEUS and the animals were sacrificed. Treated tissues were explanted for quantification of the ablation zones’ volumes. Hematoxylin and eosin (H&E) staining was also performed for histologic analysis. A total of 30 ablations were performed in the livers. The mean coagulation zone volume as measured by CEUS on day 5 after RFA was: 21.69 ± 3.39 cm3, 19.22 ± 5.77 cm3, and 8.80 ± 3.33 cm3 for N1, N2 and PS respectively. The coagulation zone volume after N1 and N2 treatments was significantly higher compared to PS treatment (p < 0.001 and p = 0.025 respectively). There was no difference between N1 and N2 treatment (p = 0.60). In our proof-of concept, pilot study we have shown for the first time that when injected directly into the target tissue during RFA, gold nanoparticles can substantially increase the coagulation zone.Tudor MocanRares StiufiucCalin PopaIuliana NenuCosmin PesteanAndras Laszlo NagyLavinia Patricia MocanDaniel Corneliu LeucutaNadim Al HajjarZeno SparchezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tudor Mocan Rares Stiufiuc Calin Popa Iuliana Nenu Cosmin Pestean Andras Laszlo Nagy Lavinia Patricia Mocan Daniel Corneliu Leucuta Nadim Al Hajjar Zeno Sparchez Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
description	Abstract To investigate the effects of PEG-coated gold nanoparticles on ablation zone volumes following in vivo radiofrequency ablation of porcine liver. This prospective study was performed following institutional animal care and committee approval was used. Radiofrequency ablations were performed in the livers of ten Sus scrofa domesticus swines. During each ablation, 10 mL (mL) of Peg-coated gold nanoparticles at two different concentrations (0.5 mg/mL and 0.01 mg/mL) were injected through the electrode channel into the target zone. For the control group, 10 mL of physiological saline was used. Five to ten minutes after each ablation, contrast enhanced ultrasound (CEUS) was performed to evaluate the volume of the coagulation zone. On day five we performed another CEUS and the animals were sacrificed. Treated tissues were explanted for quantification of the ablation zones’ volumes. Hematoxylin and eosin (H&E) staining was also performed for histologic analysis. A total of 30 ablations were performed in the livers. The mean coagulation zone volume as measured by CEUS on day 5 after RFA was: 21.69 ± 3.39 cm3, 19.22 ± 5.77 cm3, and 8.80 ± 3.33 cm3 for N1, N2 and PS respectively. The coagulation zone volume after N1 and N2 treatments was significantly higher compared to PS treatment (p < 0.001 and p = 0.025 respectively). There was no difference between N1 and N2 treatment (p = 0.60). In our proof-of concept, pilot study we have shown for the first time that when injected directly into the target tissue during RFA, gold nanoparticles can substantially increase the coagulation zone.
format	article
author	Tudor Mocan Rares Stiufiuc Calin Popa Iuliana Nenu Cosmin Pestean Andras Laszlo Nagy Lavinia Patricia Mocan Daniel Corneliu Leucuta Nadim Al Hajjar Zeno Sparchez
author_facet	Tudor Mocan Rares Stiufiuc Calin Popa Iuliana Nenu Cosmin Pestean Andras Laszlo Nagy Lavinia Patricia Mocan Daniel Corneliu Leucuta Nadim Al Hajjar Zeno Sparchez
author_sort	Tudor Mocan
title	Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
title_short	Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
title_full	Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
title_fullStr	Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
title_full_unstemmed	Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver
title_sort	percutaneous ultrasound guided peg-coated gold nanoparticles enhanced radiofrequency ablation in liver
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c79f64d15cdb4a5a80e0f3883aacbe08
work_keys_str_mv	AT tudormocan percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT raresstiufiuc percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT calinpopa percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT iuliananenu percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT cosminpestean percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT andraslaszlonagy percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT laviniapatriciamocan percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT danielcorneliuleucuta percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT nadimalhajjar percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver AT zenosparchez percutaneousultrasoundguidedpegcoatedgoldnanoparticlesenhancedradiofrequencyablationinliver
_version_	1718391810736259072

Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver

Ejemplares similares