Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study

Abstract Background Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL). Even so, fatigue is underexplored in children an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. M. ter Haar, M. M. Nap-van der Vlist, M. Van den Hof, S. L. Nijhof, R. R. L. van Litsenburg, K. J. Oostrom, D. Pajkrt
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Perinatal HIV Vertical HIV HIV-infection Pediatric Child Adolescent Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/c7a34ede45b0426583c9a0ec26cc99df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c7a34ede45b0426583c9a0ec26cc99df
record_format	dspace
spelling	oai:doaj.org-article:c7a34ede45b0426583c9a0ec26cc99df2021-11-21T12:33:20ZFatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study10.1186/s12887-021-02977-61471-2431https://doaj.org/article/c7a34ede45b0426583c9a0ec26cc99df2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02977-6https://doaj.org/toc/1471-2431Abstract Background Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL). Even so, fatigue is underexplored in children and adolescents perinatally infected with HIV (PHIV+) in the Netherlands. The objective of this observational study is to explore fatigue in PHIV+ and its association with their HRQOL. Methods We measured HRQOL and fatigue using the Pediatric Quality of Life Inventory™ (PedsQL 4.0) and the PedsQL Multidimensional Fatigue Scale (MFS). The PedsQL MFS encompasses three subscales: general fatigue, sleep/rest fatigue and cognitive fatigue, and a total fatigue score. We compared outcomes of PHIV+ children and adolescents in the Amsterdam University Medical Centre with three groups: 1) HIV-uninfected controls (HIV-) matched for age, sex, region of birth, socioeconomic status and adoption status, 2) CCD, and 3) the general Dutch population. Within the PHIV+ group we explored associations between fatigue and HRQOL. Results We enrolled 14 PHIV+ (median age 10.2 years [IQR 9.2–11.4]) and 14 HIV-. Compared to CCD, PHIV+ significantly reported less general fatigue (mean difference 13.0, 95% CI 1.3 to 24.8). PHIV+ did not score significantly different on any of the other PedsQL MFS scales compared to HIV-, CCD or the general Dutch population. PHIV children scored relatively low on the cognitive fatigue scale in comparison to HIV-uninfected matched controls, CCD and the general population, although these differences did not reach significance. Among PHIV+, a lower score on total fatigue, general fatigue and cognitive fatigue was associated with a lower HRQOL score. Conclusions The results of this study suggest that PHIV children and adolescents do not experience more symptoms of fatigue than their healthy peers. However, PHIV children and adolescents may be more likely to experience cognitive fatigue. Fatigue in PHIV also appears to be associated with children’s HRQOL. Further research should confirm these exploratory findings.A. M. ter HaarM. M. Nap-van der VlistM. Van den HofS. L. NijhofR. R. L. van LitsenburgK. J. OostromD. PajkrtBMCarticlePerinatal HIVVertical HIVHIV-infectionPediatricChildAdolescentPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Perinatal HIV Vertical HIV HIV-infection Pediatric Child Adolescent Pediatrics RJ1-570
spellingShingle	Perinatal HIV Vertical HIV HIV-infection Pediatric Child Adolescent Pediatrics RJ1-570 A. M. ter Haar M. M. Nap-van der Vlist M. Van den Hof S. L. Nijhof R. R. L. van Litsenburg K. J. Oostrom D. Pajkrt Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
description	Abstract Background Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL). Even so, fatigue is underexplored in children and adolescents perinatally infected with HIV (PHIV+) in the Netherlands. The objective of this observational study is to explore fatigue in PHIV+ and its association with their HRQOL. Methods We measured HRQOL and fatigue using the Pediatric Quality of Life Inventory™ (PedsQL 4.0) and the PedsQL Multidimensional Fatigue Scale (MFS). The PedsQL MFS encompasses three subscales: general fatigue, sleep/rest fatigue and cognitive fatigue, and a total fatigue score. We compared outcomes of PHIV+ children and adolescents in the Amsterdam University Medical Centre with three groups: 1) HIV-uninfected controls (HIV-) matched for age, sex, region of birth, socioeconomic status and adoption status, 2) CCD, and 3) the general Dutch population. Within the PHIV+ group we explored associations between fatigue and HRQOL. Results We enrolled 14 PHIV+ (median age 10.2 years [IQR 9.2–11.4]) and 14 HIV-. Compared to CCD, PHIV+ significantly reported less general fatigue (mean difference 13.0, 95% CI 1.3 to 24.8). PHIV+ did not score significantly different on any of the other PedsQL MFS scales compared to HIV-, CCD or the general Dutch population. PHIV children scored relatively low on the cognitive fatigue scale in comparison to HIV-uninfected matched controls, CCD and the general population, although these differences did not reach significance. Among PHIV+, a lower score on total fatigue, general fatigue and cognitive fatigue was associated with a lower HRQOL score. Conclusions The results of this study suggest that PHIV children and adolescents do not experience more symptoms of fatigue than their healthy peers. However, PHIV children and adolescents may be more likely to experience cognitive fatigue. Fatigue in PHIV also appears to be associated with children’s HRQOL. Further research should confirm these exploratory findings.
format	article
author	A. M. ter Haar M. M. Nap-van der Vlist M. Van den Hof S. L. Nijhof R. R. L. van Litsenburg K. J. Oostrom D. Pajkrt
author_facet	A. M. ter Haar M. M. Nap-van der Vlist M. Van den Hof S. L. Nijhof R. R. L. van Litsenburg K. J. Oostrom D. Pajkrt
author_sort	A. M. ter Haar
title	Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
title_short	Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
title_full	Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
title_fullStr	Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
title_full_unstemmed	Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
title_sort	fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c7a34ede45b0426583c9a0ec26cc99df
work_keys_str_mv	AT amterhaar fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT mmnapvandervlist fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT mvandenhof fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT slnijhof fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT rrlvanlitsenburg fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT kjoostrom fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy AT dpajkrt fatigueinchildrenandadolescentsperinatallyinfectedwithhumanimmunodeficiencyvirusanobservationalstudy
_version_	1718418970714832896

Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study

Ejemplares similares