Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer

Abstract Background The effect of schistosomiasis on CD8+ T cells and then on PD-L1 expression was unknown, and the utility of CD8+ TILs as a biomarker for schistosomal-associated colorectal cancer (SCRC) rarely has been reported. Methods Three hundred thirty-eight patients with colorectal cancer (C...

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Autores principales:	Weixia Wang, Hongyan Jing, Jican Liu, Dacheng Bu, Yingyi Zhang, Ting Zhu, Kui Lu, Yanchao Xu, Meihong Cheng, Jing Liu, Junxia Yao, Sinian Huang, Limei Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	PD-L1 CD8+ TILs Colorectal cancer Prognosis Schistosomiasis Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c7a3ebf97d884a6aad246a7784a05681
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spelling	oai:doaj.org-article:c7a3ebf97d884a6aad246a7784a056812021-11-14T12:33:42ZCorrelation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer10.1186/s12957-021-02433-w1477-7819https://doaj.org/article/c7a3ebf97d884a6aad246a7784a056812021-11-01T00:00:00Zhttps://doi.org/10.1186/s12957-021-02433-whttps://doaj.org/toc/1477-7819Abstract Background The effect of schistosomiasis on CD8+ T cells and then on PD-L1 expression was unknown, and the utility of CD8+ TILs as a biomarker for schistosomal-associated colorectal cancer (SCRC) rarely has been reported. Methods Three hundred thirty-eight patients with colorectal cancer (CRC) were enrolled. Immunohistochemical analysis was conducted to evaluate the expression of PD-L1 and the infiltration of CD8+ T cells. Results In the total cohort, the results showed that CD8+ TIL density was positively correlated with tumoral (p = 0.0001) and stromal PD-L1 expression (p = 0.0102). But there were no correlation between schistosomiasis and CD8+ TILs and PD-L1. Furthermore, CD8+ TIL density (p = 0.010), schistosomiasis (p = 0.042) were independent predictive factors for overall survival (OS). Stromal PD-L1 (sPD-L1) was correlated with OS (p = 0.046), but it was not an independent predictor. In patients without schistosomiasis, CD8 + T cells (p = 0.002) and sPD-L1 (p = 0.005) were associated with better OS. In patients with schistosomiasis, CD8 + T cells were independent prognosis factor (p = 0.045). Conclusions The study showed that CD8+ TILs was an independent predictive factor for OS in CRC and SCRC patients. The expression of PD-L1 was positively associated with CD8 + TILs density. There were no correlation between schistosomiasis and CD8 + TILs and PD-L1. Stromal PD-L1 but not tPD-L1 was significantly associated with OS, whereas it was not an independent prognostic factor.Weixia WangHongyan JingJican LiuDacheng BuYingyi ZhangTing ZhuKui LuYanchao XuMeihong ChengJing LiuJunxia YaoSinian HuangLimei WangBMCarticlePD-L1CD8+ TILsColorectal cancerPrognosisSchistosomiasisSurgeryRD1-811Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENWorld Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PD-L1 CD8+ TILs Colorectal cancer Prognosis Schistosomiasis Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	PD-L1 CD8+ TILs Colorectal cancer Prognosis Schistosomiasis Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Weixia Wang Hongyan Jing Jican Liu Dacheng Bu Yingyi Zhang Ting Zhu Kui Lu Yanchao Xu Meihong Cheng Jing Liu Junxia Yao Sinian Huang Limei Wang Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
description	Abstract Background The effect of schistosomiasis on CD8+ T cells and then on PD-L1 expression was unknown, and the utility of CD8+ TILs as a biomarker for schistosomal-associated colorectal cancer (SCRC) rarely has been reported. Methods Three hundred thirty-eight patients with colorectal cancer (CRC) were enrolled. Immunohistochemical analysis was conducted to evaluate the expression of PD-L1 and the infiltration of CD8+ T cells. Results In the total cohort, the results showed that CD8+ TIL density was positively correlated with tumoral (p = 0.0001) and stromal PD-L1 expression (p = 0.0102). But there were no correlation between schistosomiasis and CD8+ TILs and PD-L1. Furthermore, CD8+ TIL density (p = 0.010), schistosomiasis (p = 0.042) were independent predictive factors for overall survival (OS). Stromal PD-L1 (sPD-L1) was correlated with OS (p = 0.046), but it was not an independent predictor. In patients without schistosomiasis, CD8 + T cells (p = 0.002) and sPD-L1 (p = 0.005) were associated with better OS. In patients with schistosomiasis, CD8 + T cells were independent prognosis factor (p = 0.045). Conclusions The study showed that CD8+ TILs was an independent predictive factor for OS in CRC and SCRC patients. The expression of PD-L1 was positively associated with CD8 + TILs density. There were no correlation between schistosomiasis and CD8 + TILs and PD-L1. Stromal PD-L1 but not tPD-L1 was significantly associated with OS, whereas it was not an independent prognostic factor.
format	article
author	Weixia Wang Hongyan Jing Jican Liu Dacheng Bu Yingyi Zhang Ting Zhu Kui Lu Yanchao Xu Meihong Cheng Jing Liu Junxia Yao Sinian Huang Limei Wang
author_facet	Weixia Wang Hongyan Jing Jican Liu Dacheng Bu Yingyi Zhang Ting Zhu Kui Lu Yanchao Xu Meihong Cheng Jing Liu Junxia Yao Sinian Huang Limei Wang
author_sort	Weixia Wang
title	Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
title_short	Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
title_full	Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
title_fullStr	Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
title_full_unstemmed	Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
title_sort	correlation between schistosomiasis and cd8+ t cell and stromal pd-l1 as well as the different prognostic role of cd8+ t cell and pd-l1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c7a3ebf97d884a6aad246a7784a05681
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Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer

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