Direct reprogramming of adult cells: avoiding the pluripotent state

Sophia Kelaini, Amy Cochrane, Andriana Margariti Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Institute of Clinical Sciences, Belfast, UK Abstract: The procedure of using mature, fully differentiated cells and induci...

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Autores principales:	Kelaini S, Cochrane A, Margariti A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/c7a4fc1354d44c609a38289023cc65d1
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spelling	oai:doaj.org-article:c7a4fc1354d44c609a38289023cc65d12021-12-02T02:50:20ZDirect reprogramming of adult cells: avoiding the pluripotent state1178-6957https://doaj.org/article/c7a4fc1354d44c609a38289023cc65d12014-02-01T00:00:00Zhttp://www.dovepress.com/direct-reprogramming-of-adult-cells-avoiding-the-pluripotent-state-a15831https://doaj.org/toc/1178-6957 Sophia Kelaini, Amy Cochrane, Andriana Margariti Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Institute of Clinical Sciences, Belfast, UK Abstract: The procedure of using mature, fully differentiated cells and inducing them toward other cell types while bypassing an intermediate pluripotent state is termed direct reprogramming. Avoiding the pluripotent stage during cellular conversions can be achieved either through ectopic expression of lineage-specific factors (transdifferentiation) or a direct reprogramming process that involves partial reprogramming toward the pluripotent stage. Latest advances in the field seek to alleviate concerns that include teratoma formation or retroviral usage when it comes to delivering reprogramming factors to cells. They also seek to improve efficacy and efficiency of cellular conversion, both in vitro and in vivo. The final products of this reprogramming approach could be then directly implemented in regenerative and personalized medicine. Keywords: ESCs, iPS, PiPS, reprogramming, transdifferentiation, miRNAKelaini SCochrane AMargariti ADove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 19-29 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Kelaini S Cochrane A Margariti A Direct reprogramming of adult cells: avoiding the pluripotent state
description	Sophia Kelaini, Amy Cochrane, Andriana Margariti Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Institute of Clinical Sciences, Belfast, UK Abstract: The procedure of using mature, fully differentiated cells and inducing them toward other cell types while bypassing an intermediate pluripotent state is termed direct reprogramming. Avoiding the pluripotent stage during cellular conversions can be achieved either through ectopic expression of lineage-specific factors (transdifferentiation) or a direct reprogramming process that involves partial reprogramming toward the pluripotent stage. Latest advances in the field seek to alleviate concerns that include teratoma formation or retroviral usage when it comes to delivering reprogramming factors to cells. They also seek to improve efficacy and efficiency of cellular conversion, both in vitro and in vivo. The final products of this reprogramming approach could be then directly implemented in regenerative and personalized medicine. Keywords: ESCs, iPS, PiPS, reprogramming, transdifferentiation, miRNA
format	article
author	Kelaini S Cochrane A Margariti A
author_facet	Kelaini S Cochrane A Margariti A
author_sort	Kelaini S
title	Direct reprogramming of adult cells: avoiding the pluripotent state
title_short	Direct reprogramming of adult cells: avoiding the pluripotent state
title_full	Direct reprogramming of adult cells: avoiding the pluripotent state
title_fullStr	Direct reprogramming of adult cells: avoiding the pluripotent state
title_full_unstemmed	Direct reprogramming of adult cells: avoiding the pluripotent state
title_sort	direct reprogramming of adult cells: avoiding the pluripotent state
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/c7a4fc1354d44c609a38289023cc65d1
work_keys_str_mv	AT kelainis directreprogrammingofadultcellsavoidingthepluripotentstate AT cochranea directreprogrammingofadultcellsavoidingthepluripotentstate AT margaritia directreprogrammingofadultcellsavoidingthepluripotentstate
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Direct reprogramming of adult cells: avoiding the pluripotent state

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