Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Abstract Purpose The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance. Methods A cross-sectional study of 88 overweight/obese adults who underwent anthro...

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Autores principales:	Danyan Ma, Jinyang Zeng, Bingkun Huang, Fangfang Yan, Jiawen Ye, Yun Chen, Xiying Zeng, Xin Zheng, Fangsen Xiao, Mingzhu Lin, Changqin Liu, Zhibin Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hepatic steatosis Insulin resistance Free triiodothyronine (FT3) Controlled attenuation parameter (CAP) Fatty liver index (FLI) Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/c7a934200f6347acbdec6cb4e2f903db
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spelling	oai:doaj.org-article:c7a934200f6347acbdec6cb4e2f903db2021-11-21T12:15:34ZIndependent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults10.1186/s12876-021-02011-01471-230Xhttps://doaj.org/article/c7a934200f6347acbdec6cb4e2f903db2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02011-0https://doaj.org/toc/1471-230XAbstract Purpose The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance. Methods A cross-sectional study of 88 overweight/obese adults who underwent anthropometric measurements [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)], hepatic steatosis assessment (FibroScan) and thyroid-related hormones tests was conducted from 2018 to 2020 in Xiamen, China. Results Subjects with increasing tertiles of FT3 showed significantly higher levels of controlled attenuation parameter (CAP) ((295.4 ± 44.1, 290.1 ± 68.2 and 331.7 ± 43.6 (dB/m) for tertile 1–3, respectively, p = 0.007) and fatty liver index (FLI) score (47.7 (33.9–60.8), 61.5 (45.1–88.9) and 90.5 (84.5–94.8), respectively, p < 0.001). FT3 significantly and positively correlated with obesity index (BMI, WC, and WHtR), homeostatic model assessment of insulin resistance (HOMA-IR) and hepatic steatosis (CAP and FLI). Multivariable linear regression analyses with adjustment for potential confounding factors showed FT3 was independently associated with BMI (regression coefficient (β (95%CI): 0.024 (0.004–0.043), p = 0.020), HOMA-IR (β (95%CI): 0.091 (0.007–0.174), p = 0.034), CAP (β (95%CI): 25.45 (2.59–48.31), p = 0.030) and FLI (β (95%CI): 0.121 (0.049–0.194), p = 0.001). Neither FT4 nor TSH was significantly associated with any indicators of obesity, insulin resistance or hepatic steatosis. Conclusions Increased FT3, but not FT4 or TSH, was independently associated with higher risks of hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. Trial registration Registration is not applicable for our study.Danyan MaJinyang ZengBingkun HuangFangfang YanJiawen YeYun ChenXiying ZengXin ZhengFangsen XiaoMingzhu LinChangqin LiuZhibin LiBMCarticleHepatic steatosisInsulin resistanceFree triiodothyronine (FT3)Controlled attenuation parameter (CAP)Fatty liver index (FLI)Diseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatic steatosis Insulin resistance Free triiodothyronine (FT3) Controlled attenuation parameter (CAP) Fatty liver index (FLI) Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Hepatic steatosis Insulin resistance Free triiodothyronine (FT3) Controlled attenuation parameter (CAP) Fatty liver index (FLI) Diseases of the digestive system. Gastroenterology RC799-869 Danyan Ma Jinyang Zeng Bingkun Huang Fangfang Yan Jiawen Ye Yun Chen Xiying Zeng Xin Zheng Fangsen Xiao Mingzhu Lin Changqin Liu Zhibin Li Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
description	Abstract Purpose The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance. Methods A cross-sectional study of 88 overweight/obese adults who underwent anthropometric measurements [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)], hepatic steatosis assessment (FibroScan) and thyroid-related hormones tests was conducted from 2018 to 2020 in Xiamen, China. Results Subjects with increasing tertiles of FT3 showed significantly higher levels of controlled attenuation parameter (CAP) ((295.4 ± 44.1, 290.1 ± 68.2 and 331.7 ± 43.6 (dB/m) for tertile 1–3, respectively, p = 0.007) and fatty liver index (FLI) score (47.7 (33.9–60.8), 61.5 (45.1–88.9) and 90.5 (84.5–94.8), respectively, p < 0.001). FT3 significantly and positively correlated with obesity index (BMI, WC, and WHtR), homeostatic model assessment of insulin resistance (HOMA-IR) and hepatic steatosis (CAP and FLI). Multivariable linear regression analyses with adjustment for potential confounding factors showed FT3 was independently associated with BMI (regression coefficient (β (95%CI): 0.024 (0.004–0.043), p = 0.020), HOMA-IR (β (95%CI): 0.091 (0.007–0.174), p = 0.034), CAP (β (95%CI): 25.45 (2.59–48.31), p = 0.030) and FLI (β (95%CI): 0.121 (0.049–0.194), p = 0.001). Neither FT4 nor TSH was significantly associated with any indicators of obesity, insulin resistance or hepatic steatosis. Conclusions Increased FT3, but not FT4 or TSH, was independently associated with higher risks of hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. Trial registration Registration is not applicable for our study.
format	article
author	Danyan Ma Jinyang Zeng Bingkun Huang Fangfang Yan Jiawen Ye Yun Chen Xiying Zeng Xin Zheng Fangsen Xiao Mingzhu Lin Changqin Liu Zhibin Li
author_facet	Danyan Ma Jinyang Zeng Bingkun Huang Fangfang Yan Jiawen Ye Yun Chen Xiying Zeng Xin Zheng Fangsen Xiao Mingzhu Lin Changqin Liu Zhibin Li
author_sort	Danyan Ma
title	Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
title_short	Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
title_full	Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
title_fullStr	Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
title_full_unstemmed	Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults
title_sort	independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese chinese adults
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c7a934200f6347acbdec6cb4e2f903db
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Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

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