TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis.
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in aut...
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2011
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oai:doaj.org-article:c7aae3513d1d4f4fad2410fe3ab3433e2021-11-18T06:49:43ZTRAIL/TRAIL receptor system and susceptibility to multiple sclerosis.1932-620310.1371/journal.pone.0021766https://doaj.org/article/c7aae3513d1d4f4fad2410fe3ab3433e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21814551/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4), OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5), OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS.Carlos López-GómezOscar FernándezJuan Antonio García-LeónMaría Jesús Pinto-MedelBegoña Oliver-MartosJesús Ortega-PinazoMargarita SuardíazLucía García-TrujilloCristina Guijarro-CastroJulián Benito-LeónIsidro PratJezabel VaradéRoberto Álvarez-LafuenteElena UrcelayLaura LeyvaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21766 (2011) |
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Medicine R Science Q Carlos López-Gómez Oscar Fernández Juan Antonio García-León María Jesús Pinto-Medel Begoña Oliver-Martos Jesús Ortega-Pinazo Margarita Suardíaz Lucía García-Trujillo Cristina Guijarro-Castro Julián Benito-León Isidro Prat Jezabel Varadé Roberto Álvarez-Lafuente Elena Urcelay Laura Leyva TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| description |
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4), OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5), OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS. |
| format |
article |
| author |
Carlos López-Gómez Oscar Fernández Juan Antonio García-León María Jesús Pinto-Medel Begoña Oliver-Martos Jesús Ortega-Pinazo Margarita Suardíaz Lucía García-Trujillo Cristina Guijarro-Castro Julián Benito-León Isidro Prat Jezabel Varadé Roberto Álvarez-Lafuente Elena Urcelay Laura Leyva |
| author_facet |
Carlos López-Gómez Oscar Fernández Juan Antonio García-León María Jesús Pinto-Medel Begoña Oliver-Martos Jesús Ortega-Pinazo Margarita Suardíaz Lucía García-Trujillo Cristina Guijarro-Castro Julián Benito-León Isidro Prat Jezabel Varadé Roberto Álvarez-Lafuente Elena Urcelay Laura Leyva |
| author_sort |
Carlos López-Gómez |
| title |
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| title_short |
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| title_full |
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| title_fullStr |
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| title_full_unstemmed |
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. |
| title_sort |
trail/trail receptor system and susceptibility to multiple sclerosis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/c7aae3513d1d4f4fad2410fe3ab3433e |
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