Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2

Abstract To trace the evolution of coronaviruses and reveal the possible origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), we collected and thoroughly analyzed 29,452 publicly available coronavirus genomes, including 26,...

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Autores principales:	Zhenglin Zhu, Kaiwen Meng, Geng Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7ab03e0a70640069a49796ea02ab88b
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spelling	oai:doaj.org-article:c7ab03e0a70640069a49796ea02ab88b2021-12-02T15:11:52ZGenomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-210.1038/s41598-020-78703-62045-2322https://doaj.org/article/c7ab03e0a70640069a49796ea02ab88b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78703-6https://doaj.org/toc/2045-2322Abstract To trace the evolution of coronaviruses and reveal the possible origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), we collected and thoroughly analyzed 29,452 publicly available coronavirus genomes, including 26,312 genomes of SARS-CoV-2 strains. We observed coronavirus recombination events among different hosts including 3 independent recombination events with statistical significance between some isolates from humans, bats and pangolins. Consistent with previous records, we also detected putative recombination between strains similar or related to Bat-CoV-RaTG13 and Pangolin-CoV-2019. The putative recombination region is located inside the receptor-binding domain (RBD) of the spike glycoprotein (S protein), which may represent the origin of SARS-CoV-2. Population genetic analyses provide estimates suggesting that the putative introduced DNA within the RBD is undergoing directional evolution. This may result in the adaptation of the virus to hosts. Unsurprisingly, we found that the putative recombination region in S protein was highly diverse among strains from bats. Bats harbor numerous coronavirus subclades that frequently participate in recombination events with human coronavirus. Therefore, bats may provide a pool of genetic diversity for the origin of SARS-CoV-2.Zhenglin ZhuKaiwen MengGeng MengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhenglin Zhu Kaiwen Meng Geng Meng Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
description	Abstract To trace the evolution of coronaviruses and reveal the possible origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), we collected and thoroughly analyzed 29,452 publicly available coronavirus genomes, including 26,312 genomes of SARS-CoV-2 strains. We observed coronavirus recombination events among different hosts including 3 independent recombination events with statistical significance between some isolates from humans, bats and pangolins. Consistent with previous records, we also detected putative recombination between strains similar or related to Bat-CoV-RaTG13 and Pangolin-CoV-2019. The putative recombination region is located inside the receptor-binding domain (RBD) of the spike glycoprotein (S protein), which may represent the origin of SARS-CoV-2. Population genetic analyses provide estimates suggesting that the putative introduced DNA within the RBD is undergoing directional evolution. This may result in the adaptation of the virus to hosts. Unsurprisingly, we found that the putative recombination region in S protein was highly diverse among strains from bats. Bats harbor numerous coronavirus subclades that frequently participate in recombination events with human coronavirus. Therefore, bats may provide a pool of genetic diversity for the origin of SARS-CoV-2.
format	article
author	Zhenglin Zhu Kaiwen Meng Geng Meng
author_facet	Zhenglin Zhu Kaiwen Meng Geng Meng
author_sort	Zhenglin Zhu
title	Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
title_short	Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
title_full	Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
title_fullStr	Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
title_full_unstemmed	Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2
title_sort	genomic recombination events may reveal the evolution of coronavirus and the origin of sars-cov-2
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c7ab03e0a70640069a49796ea02ab88b
work_keys_str_mv	AT zhenglinzhu genomicrecombinationeventsmayrevealtheevolutionofcoronavirusandtheoriginofsarscov2 AT kaiwenmeng genomicrecombinationeventsmayrevealtheevolutionofcoronavirusandtheoriginofsarscov2 AT gengmeng genomicrecombinationeventsmayrevealtheevolutionofcoronavirusandtheoriginofsarscov2
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Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2

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