Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.

Lymphatic filariasis (LF) is a mosquito-transmitted parasitic disease that is a leading cause of disability globally. The island of Hispaniola, which the Dominican Republic shares with Haiti, accounts for approximately 90% of LF cases in the Americas region. In 1998, the Dominican Ministry of Public...

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Autores principales:	Manuel Gonzales, Gregory S Noland, Eileen F Mariano, Stephen Blount
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/c7ad52ebbe254dc0b90bdd59282366c1
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spelling	oai:doaj.org-article:c7ad52ebbe254dc0b90bdd59282366c12021-12-02T20:23:41ZLymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.1935-27271935-273510.1371/journal.pntd.0009590https://doaj.org/article/c7ad52ebbe254dc0b90bdd59282366c12021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009590https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Lymphatic filariasis (LF) is a mosquito-transmitted parasitic disease that is a leading cause of disability globally. The island of Hispaniola, which the Dominican Republic shares with Haiti, accounts for approximately 90% of LF cases in the Americas region. In 1998, the Dominican Ministry of Public Health created the Program to Eliminate Lymphatic Filariasis (PELF) with the goal of eliminating LF transmission by 2020. Baseline mapping revealed 19 (12% of total) endemic municipalities clustered into three geographic foci (Southwest, La Ciénaga and East), with a total at-risk population of 262,395 people. Beginning in 2002, PELF sequentially implemented mass drug administration (MDA) in these foci using albendazole and diethylcarbamazine (DEC). In total, 1,174,050 treatments were given over three to five annual rounds of house-to-house MDA per focus with a median coverage of 81.7% (range 67.4%-92.2%). By 2018, LF antigen prevalence was less than 2% in all foci, thus meeting criteria to stop MDA and begin post-treatment surveillance (PTS). This success has been achieved against a shifting landscape of limited domestic funding, competing domestic public health priorities, and sporadic external donor support. Remaining steps include the need to scale-up morbidity management and disability prevention services for LF and to continue PTS until LF transmission is interrupted across Hispaniola.Manuel GonzalesGregory S NolandEileen F MarianoStephen BlountPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009590 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Manuel Gonzales Gregory S Noland Eileen F Mariano Stephen Blount Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
description	Lymphatic filariasis (LF) is a mosquito-transmitted parasitic disease that is a leading cause of disability globally. The island of Hispaniola, which the Dominican Republic shares with Haiti, accounts for approximately 90% of LF cases in the Americas region. In 1998, the Dominican Ministry of Public Health created the Program to Eliminate Lymphatic Filariasis (PELF) with the goal of eliminating LF transmission by 2020. Baseline mapping revealed 19 (12% of total) endemic municipalities clustered into three geographic foci (Southwest, La Ciénaga and East), with a total at-risk population of 262,395 people. Beginning in 2002, PELF sequentially implemented mass drug administration (MDA) in these foci using albendazole and diethylcarbamazine (DEC). In total, 1,174,050 treatments were given over three to five annual rounds of house-to-house MDA per focus with a median coverage of 81.7% (range 67.4%-92.2%). By 2018, LF antigen prevalence was less than 2% in all foci, thus meeting criteria to stop MDA and begin post-treatment surveillance (PTS). This success has been achieved against a shifting landscape of limited domestic funding, competing domestic public health priorities, and sporadic external donor support. Remaining steps include the need to scale-up morbidity management and disability prevention services for LF and to continue PTS until LF transmission is interrupted across Hispaniola.
format	article
author	Manuel Gonzales Gregory S Noland Eileen F Mariano Stephen Blount
author_facet	Manuel Gonzales Gregory S Noland Eileen F Mariano Stephen Blount
author_sort	Manuel Gonzales
title	Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
title_short	Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
title_full	Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
title_fullStr	Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
title_full_unstemmed	Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.
title_sort	lymphatic filariasis elimination in the dominican republic: history, progress, and remaining steps.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c7ad52ebbe254dc0b90bdd59282366c1
work_keys_str_mv	AT manuelgonzales lymphaticfilariasiseliminationinthedominicanrepublichistoryprogressandremainingsteps AT gregorysnoland lymphaticfilariasiseliminationinthedominicanrepublichistoryprogressandremainingsteps AT eileenfmariano lymphaticfilariasiseliminationinthedominicanrepublichistoryprogressandremainingsteps AT stephenblount lymphaticfilariasiseliminationinthedominicanrepublichistoryprogressandremainingsteps
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Lymphatic filariasis elimination in the Dominican Republic: History, progress, and remaining steps.

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