Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report

Background: Gastrointestinal stromal tumor [GIST] is commonest mesenchymal tumor, mainly affects adults. But, 1.5% to 2% GISTs were reported in pediatrics and adolescents. The treatment of GIST is managed as in adult because of lack of information about pediatric GIST. Aim of the work: Here we pres...

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Autor principal:	Abdulmohsen Alsuwaigh
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	pediatrics adolescents small intestine gastrointestinal stromal tumor management Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c7ae51d5e4cf4431a345306f95c15c97
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spelling	oai:doaj.org-article:c7ae51d5e4cf4431a345306f95c15c972021-12-02T15:22:19ZPediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report2636-41742682-378010.21608/ijma.2019.63221https://doaj.org/article/c7ae51d5e4cf4431a345306f95c15c972020-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_63221_74f5db84f1fb522540512a70b47c437b.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Gastrointestinal stromal tumor [GIST] is commonest mesenchymal tumor, mainly affects adults. But, 1.5% to 2% GISTs were reported in pediatrics and adolescents. The treatment of GIST is managed as in adult because of lack of information about pediatric GIST. Aim of the work: Here we presented a case report of pediatric GIST. Current literature was reviewed and a summary was formulated to form a base for future optimal treatment of childhood GIST. Case summary: A 14 years Saudi female presented with vague abdominal pain and easy fatigability for 8 months. The pain located in lower abdomen, mild, waning, no aggravation or reliving factor and not radiating. Clinically, there was peri umbilical round, firm and not tender mass extending to right side of the abdomen till right hypochondrium, with no movement with respiratory movements. Investigations demonstrate severe microcytic hypochromic anemia. A computed tomography [CT] abdomen and pelvis showed evidence of soft tissue mass, about 131112cm, of heterogeneous pattern and enhancement with area of hypodensity and cystic degeneration. There was necrosis of mesentery with some calcification seen inside the lesion suggestive of query GIST or Lymphoma. En block resection of the mass done with safety margin, biopsy from lymph node and side-to-side anastomosis done using linear stapler. The histopathological examination revealed ill and well defined fasicles of tumor cells that have spindle, oval and round shape nuclei invading mesentery and small bowel. Mitotic figurer 5-10/50 HPF, reactive lymph node. Immunohistochemistry showed diffused strong positive CD117 and CD34, negative S-100Abdulmohsen AlsuwaighAl-Azhar University, Faculty of Medicine (Damietta)articlepediatricsadolescentssmall intestinegastrointestinal stromal tumormanagementMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 1, Pp 199-203 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pediatrics adolescents small intestine gastrointestinal stromal tumor management Medicine (General) R5-920
spellingShingle	pediatrics adolescents small intestine gastrointestinal stromal tumor management Medicine (General) R5-920 Abdulmohsen Alsuwaigh Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
description	Background: Gastrointestinal stromal tumor [GIST] is commonest mesenchymal tumor, mainly affects adults. But, 1.5% to 2% GISTs were reported in pediatrics and adolescents. The treatment of GIST is managed as in adult because of lack of information about pediatric GIST. Aim of the work: Here we presented a case report of pediatric GIST. Current literature was reviewed and a summary was formulated to form a base for future optimal treatment of childhood GIST. Case summary: A 14 years Saudi female presented with vague abdominal pain and easy fatigability for 8 months. The pain located in lower abdomen, mild, waning, no aggravation or reliving factor and not radiating. Clinically, there was peri umbilical round, firm and not tender mass extending to right side of the abdomen till right hypochondrium, with no movement with respiratory movements. Investigations demonstrate severe microcytic hypochromic anemia. A computed tomography [CT] abdomen and pelvis showed evidence of soft tissue mass, about 131112cm, of heterogeneous pattern and enhancement with area of hypodensity and cystic degeneration. There was necrosis of mesentery with some calcification seen inside the lesion suggestive of query GIST or Lymphoma. En block resection of the mass done with safety margin, biopsy from lymph node and side-to-side anastomosis done using linear stapler. The histopathological examination revealed ill and well defined fasicles of tumor cells that have spindle, oval and round shape nuclei invading mesentery and small bowel. Mitotic figurer 5-10/50 HPF, reactive lymph node. Immunohistochemistry showed diffused strong positive CD117 and CD34, negative S-100
format	article
author	Abdulmohsen Alsuwaigh
author_facet	Abdulmohsen Alsuwaigh
author_sort	Abdulmohsen Alsuwaigh
title	Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
title_short	Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
title_full	Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
title_fullStr	Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
title_full_unstemmed	Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report
title_sort	pediatric female with adult type small intestine gastrointestinal stromal tumor [gist]: a case report
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/c7ae51d5e4cf4431a345306f95c15c97
work_keys_str_mv	AT abdulmohsenalsuwaigh pediatricfemalewithadulttypesmallintestinegastrointestinalstromaltumorgistacasereport
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Pediatric Female with Adult Type Small Intestine Gastrointestinal Stromal Tumor [GIST]: A case report

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