Rapid detection of identity-by-descent tracts for mega-scale datasets

Traditional methods to identify genomic regions identical-by-descent (IBD) do not scale well to biobank-level datasets. Here, the authors describe a new IBD algorithm, iLASH, which uses LocAlity-Sensitive Hashing to provide rapid IBD estimation when applied to the PAGE and UK Biobank datasets.

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Autores principales:	Ruhollah Shemirani, Gillian M. Belbin, Christy L. Avery, Eimear E. Kenny, Christopher R. Gignoux, José Luis Ambite
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7b3497a4cd842899292bfe4b6e220f6
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spelling	oai:doaj.org-article:c7b3497a4cd842899292bfe4b6e220f62021-12-02T14:58:18ZRapid detection of identity-by-descent tracts for mega-scale datasets10.1038/s41467-021-22910-w2041-1723https://doaj.org/article/c7b3497a4cd842899292bfe4b6e220f62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22910-whttps://doaj.org/toc/2041-1723Traditional methods to identify genomic regions identical-by-descent (IBD) do not scale well to biobank-level datasets. Here, the authors describe a new IBD algorithm, iLASH, which uses LocAlity-Sensitive Hashing to provide rapid IBD estimation when applied to the PAGE and UK Biobank datasets.Ruhollah ShemiraniGillian M. BelbinChristy L. AveryEimear E. KennyChristopher R. GignouxJosé Luis AmbiteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruhollah Shemirani Gillian M. Belbin Christy L. Avery Eimear E. Kenny Christopher R. Gignoux José Luis Ambite Rapid detection of identity-by-descent tracts for mega-scale datasets
description	Traditional methods to identify genomic regions identical-by-descent (IBD) do not scale well to biobank-level datasets. Here, the authors describe a new IBD algorithm, iLASH, which uses LocAlity-Sensitive Hashing to provide rapid IBD estimation when applied to the PAGE and UK Biobank datasets.
format	article
author	Ruhollah Shemirani Gillian M. Belbin Christy L. Avery Eimear E. Kenny Christopher R. Gignoux José Luis Ambite
author_facet	Ruhollah Shemirani Gillian M. Belbin Christy L. Avery Eimear E. Kenny Christopher R. Gignoux José Luis Ambite
author_sort	Ruhollah Shemirani
title	Rapid detection of identity-by-descent tracts for mega-scale datasets
title_short	Rapid detection of identity-by-descent tracts for mega-scale datasets
title_full	Rapid detection of identity-by-descent tracts for mega-scale datasets
title_fullStr	Rapid detection of identity-by-descent tracts for mega-scale datasets
title_full_unstemmed	Rapid detection of identity-by-descent tracts for mega-scale datasets
title_sort	rapid detection of identity-by-descent tracts for mega-scale datasets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7b3497a4cd842899292bfe4b6e220f6
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Rapid detection of identity-by-descent tracts for mega-scale datasets

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