Effect of obstructive cholestasis on sex axis in the adult male rats
Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relati...
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Babol University of Medical Sciences
2003
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oai:doaj.org-article:c7b99bcf56e94e8caa976b7e700f79cf2021-11-10T09:18:21ZEffect of obstructive cholestasis on sex axis in the adult male rats1561-41072251-7170https://doaj.org/article/c7b99bcf56e94e8caa976b7e700f79cf2003-10-01T00:00:00Zhttp://jbums.org/article-1-2743-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relationship between obstructive cholestasis and sex axis in adult male rats. Methods: To study the topic, three groups of animals were used: No-surgery, sham-surgery, and surgical ligation of the bile duct. After 3 weeks, all animals were killed by ether. Serum concentration levels of inhibin B, FSH and LH were determined by ELISA and RIA, respectively. Findings: The level of inhibin B was significantly higher in cholestasis than control and sham, and serum FSH and LH were significantly higher in control and sham than cholestasis (P<0.05). Conclusion: The results showed that obstructive cholestasis decreased the levels of serum gonadotropins but in did not damage testicular functions.E NasiriMH NooriAR DehpourM BarbarestaniAK Amir ZargarM AkbariM Pour GhasemBabol University of Medical Sciencesarticleobstructive cholestasisfshlhinhibin bMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 5, Iss 4, Pp 7-10 (2003) |
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obstructive cholestasis fsh lh inhibin b Medicine R Medicine (General) R5-920 |
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obstructive cholestasis fsh lh inhibin b Medicine R Medicine (General) R5-920 E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem Effect of obstructive cholestasis on sex axis in the adult male rats |
| description |
Background and Objective: Obstructive cholestasis is associated with overproduction of some materials such as endogenous opioids (EOP) and nitric oxide (NO) in the blood streams. Physiology of sex axis hormones could be affected by some of these changes. This study was done to investigate the relationship between obstructive cholestasis and sex axis in adult male rats. Methods: To study the topic, three groups of animals were used: No-surgery, sham-surgery, and surgical ligation of the bile duct. After 3 weeks, all animals were killed by ether. Serum concentration levels of inhibin B, FSH and LH were determined by ELISA and RIA, respectively. Findings: The level of inhibin B was significantly higher in cholestasis than control and sham, and serum FSH and LH were significantly higher in control and sham than cholestasis (P<0.05). Conclusion: The results showed that obstructive cholestasis decreased the levels of serum gonadotropins but in did not damage testicular functions. |
| format |
article |
| author |
E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem |
| author_facet |
E Nasiri MH Noori AR Dehpour M Barbarestani AK Amir Zargar M Akbari M Pour Ghasem |
| author_sort |
E Nasiri |
| title |
Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_short |
Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_full |
Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_fullStr |
Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_full_unstemmed |
Effect of obstructive cholestasis on sex axis in the adult male rats |
| title_sort |
effect of obstructive cholestasis on sex axis in the adult male rats |
| publisher |
Babol University of Medical Sciences |
| publishDate |
2003 |
| url |
https://doaj.org/article/c7b99bcf56e94e8caa976b7e700f79cf |
| work_keys_str_mv |
AT enasiri effectofobstructivecholestasisonsexaxisintheadultmalerats AT mhnoori effectofobstructivecholestasisonsexaxisintheadultmalerats AT ardehpour effectofobstructivecholestasisonsexaxisintheadultmalerats AT mbarbarestani effectofobstructivecholestasisonsexaxisintheadultmalerats AT akamirzargar effectofobstructivecholestasisonsexaxisintheadultmalerats AT makbari effectofobstructivecholestasisonsexaxisintheadultmalerats AT mpourghasem effectofobstructivecholestasisonsexaxisintheadultmalerats |
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