Efferocytosis in the Central Nervous System

The effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury. In most cases of physiological apoptotic cell death, efferocytosis prevents inflammation and other pathological conditions. When apoptotic cells ar...

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Autores principales:	Jiayi Zhao, Weiqi Zhang, Tingting Wu, Hongyi Wang, Jialiang Mao, Jian Liu, Ziheng Zhou, Xianfeng Lin, Huige Yan, Qingqing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	efferocytosis apoptosis homeostasis inflammation central neural system Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c7bfbeee7b694395b87f93b424a5c9b3
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spelling	oai:doaj.org-article:c7bfbeee7b694395b87f93b424a5c9b32021-12-03T09:18:17ZEfferocytosis in the Central Nervous System2296-634X10.3389/fcell.2021.773344https://doaj.org/article/c7bfbeee7b694395b87f93b424a5c9b32021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.773344/fullhttps://doaj.org/toc/2296-634XThe effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury. In most cases of physiological apoptotic cell death, efferocytosis prevents inflammation and other pathological conditions. When apoptotic cells are not effectively cleared, destruction of the integrity of the apoptotic cell membrane integrity, leakage of intracellular contents, and secondary necrosis may occur. Efferocytosis is the mechanism by which efferocytes quickly remove apoptotic cells from tissues before they undergo secondary necrosis. Cells with efferocytosis functions, mainly microglia, help to eliminate apoptotic cells from the CNS. Here, we discuss the impacts of efferocytosis on homeostasis, the mechanism of efferocytosis, the associations of efferocytosis failure and CNS diseases, and the current clinical applications of efferocytosis. We also identify efferocytosis as a novel potential target for exploring the causes and treatments of CNS diseases.Jiayi ZhaoWeiqi ZhangTingting WuHongyi WangJialiang MaoJian LiuZiheng ZhouXianfeng LinHuige YanQingqing WangFrontiers Media S.A.articleefferocytosisapoptosishomeostasisinflammationcentral neural systemBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	efferocytosis apoptosis homeostasis inflammation central neural system Biology (General) QH301-705.5
spellingShingle	efferocytosis apoptosis homeostasis inflammation central neural system Biology (General) QH301-705.5 Jiayi Zhao Weiqi Zhang Tingting Wu Hongyi Wang Jialiang Mao Jian Liu Ziheng Zhou Xianfeng Lin Huige Yan Qingqing Wang Efferocytosis in the Central Nervous System
description	The effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury. In most cases of physiological apoptotic cell death, efferocytosis prevents inflammation and other pathological conditions. When apoptotic cells are not effectively cleared, destruction of the integrity of the apoptotic cell membrane integrity, leakage of intracellular contents, and secondary necrosis may occur. Efferocytosis is the mechanism by which efferocytes quickly remove apoptotic cells from tissues before they undergo secondary necrosis. Cells with efferocytosis functions, mainly microglia, help to eliminate apoptotic cells from the CNS. Here, we discuss the impacts of efferocytosis on homeostasis, the mechanism of efferocytosis, the associations of efferocytosis failure and CNS diseases, and the current clinical applications of efferocytosis. We also identify efferocytosis as a novel potential target for exploring the causes and treatments of CNS diseases.
format	article
author	Jiayi Zhao Weiqi Zhang Tingting Wu Hongyi Wang Jialiang Mao Jian Liu Ziheng Zhou Xianfeng Lin Huige Yan Qingqing Wang
author_facet	Jiayi Zhao Weiqi Zhang Tingting Wu Hongyi Wang Jialiang Mao Jian Liu Ziheng Zhou Xianfeng Lin Huige Yan Qingqing Wang
author_sort	Jiayi Zhao
title	Efferocytosis in the Central Nervous System
title_short	Efferocytosis in the Central Nervous System
title_full	Efferocytosis in the Central Nervous System
title_fullStr	Efferocytosis in the Central Nervous System
title_full_unstemmed	Efferocytosis in the Central Nervous System
title_sort	efferocytosis in the central nervous system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c7bfbeee7b694395b87f93b424a5c9b3
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Efferocytosis in the Central Nervous System

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