Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults

Although several indices used in clinical practice identify cardiometabolic risk (CR) and metabolic syndrome (MetS), it is imperative to develop indices for specific populations. Therefore, we proposed and validated sex-specific indices to identify CR associated with visceral adipose tissue (VAT) ac...

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Autores principales:	Patricia Lizett Rodríguez-Carrillo, Priscila Irene Aguirre-Tostado, Maciste H. Macías-Cervantes, Jorge Alejandro Alegría-Torres, Claudia Luevano-Contreras
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	visceral adipose tissue cardiometabolic risk metabolic syndrome adiposity indices insulin resistance indices Medicine R
Acceso en línea:	https://doaj.org/article/c7c0f7dea52949e4a6b6df54c0e1019b
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spelling	oai:doaj.org-article:c7c0f7dea52949e4a6b6df54c0e1019b2021-11-25T17:46:18ZNovel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults10.3390/healthcare91115612227-9032https://doaj.org/article/c7c0f7dea52949e4a6b6df54c0e1019b2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1561https://doaj.org/toc/2227-9032Although several indices used in clinical practice identify cardiometabolic risk (CR) and metabolic syndrome (MetS), it is imperative to develop indices for specific populations. Therefore, we proposed and validated sex-specific indices to identify CR associated with visceral adipose tissue (VAT) accumulation or MetS in Mexican adults. Additionally, a cut-off value for the visceral fat area (VFA) to identify CR was proposed. Clinical, anthropometric, biochemical, and body composition variables were evaluated in 904 subjects (25–45 years old) (84.4% men). Multiple and logistic regressions were used to model the indices and ROC curve analysis to determine predictive performance. An additional cohort (<i>n</i> = 186) was used for indices validation, and Cohen’s kappa coefficient was employed for agreement analysis. The proposed sex-specific indices, called Mexican adiposity indices (MAIs) and biochemical–anthropometric indices (BAIs), were good predictors for CR and MetS. The kappa coefficients showed a moderate agreement level. The VFA cut-off value chosen to identify CR was 100.3 cm<sup>2</sup> because it had the best combination of sensitivity (66.8%) and specificity (64.4%). MAIs and BAIs could be clinical tools to identify either CR associated to VAT accumulation or MetS, respectively. A VFA cut-off value of 100.3 cm<sup>2</sup> could identify CR in Mexican men.Patricia Lizett Rodríguez-CarrilloPriscila Irene Aguirre-TostadoMaciste H. Macías-CervantesJorge Alejandro Alegría-TorresClaudia Luevano-ContrerasMDPI AGarticlevisceral adipose tissuecardiometabolic riskmetabolic syndromeadiposity indicesinsulin resistance indicesMedicineRENHealthcare, Vol 9, Iss 1561, p 1561 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	visceral adipose tissue cardiometabolic risk metabolic syndrome adiposity indices insulin resistance indices Medicine R
spellingShingle	visceral adipose tissue cardiometabolic risk metabolic syndrome adiposity indices insulin resistance indices Medicine R Patricia Lizett Rodríguez-Carrillo Priscila Irene Aguirre-Tostado Maciste H. Macías-Cervantes Jorge Alejandro Alegría-Torres Claudia Luevano-Contreras Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
description	Although several indices used in clinical practice identify cardiometabolic risk (CR) and metabolic syndrome (MetS), it is imperative to develop indices for specific populations. Therefore, we proposed and validated sex-specific indices to identify CR associated with visceral adipose tissue (VAT) accumulation or MetS in Mexican adults. Additionally, a cut-off value for the visceral fat area (VFA) to identify CR was proposed. Clinical, anthropometric, biochemical, and body composition variables were evaluated in 904 subjects (25–45 years old) (84.4% men). Multiple and logistic regressions were used to model the indices and ROC curve analysis to determine predictive performance. An additional cohort (<i>n</i> = 186) was used for indices validation, and Cohen’s kappa coefficient was employed for agreement analysis. The proposed sex-specific indices, called Mexican adiposity indices (MAIs) and biochemical–anthropometric indices (BAIs), were good predictors for CR and MetS. The kappa coefficients showed a moderate agreement level. The VFA cut-off value chosen to identify CR was 100.3 cm<sup>2</sup> because it had the best combination of sensitivity (66.8%) and specificity (64.4%). MAIs and BAIs could be clinical tools to identify either CR associated to VAT accumulation or MetS, respectively. A VFA cut-off value of 100.3 cm<sup>2</sup> could identify CR in Mexican men.
format	article
author	Patricia Lizett Rodríguez-Carrillo Priscila Irene Aguirre-Tostado Maciste H. Macías-Cervantes Jorge Alejandro Alegría-Torres Claudia Luevano-Contreras
author_facet	Patricia Lizett Rodríguez-Carrillo Priscila Irene Aguirre-Tostado Maciste H. Macías-Cervantes Jorge Alejandro Alegría-Torres Claudia Luevano-Contreras
author_sort	Patricia Lizett Rodríguez-Carrillo
title	Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
title_short	Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
title_full	Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
title_fullStr	Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
title_full_unstemmed	Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults
title_sort	novel adiposity and biochemical–anthropometric indices to identify cardiometabolic risk and metabolic syndrome in mexican adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c7c0f7dea52949e4a6b6df54c0e1019b
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Novel Adiposity and Biochemical–Anthropometric Indices to Identify Cardiometabolic Risk and Metabolic Syndrome in Mexican Adults

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