Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive ma...

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Autores principales:	Tomer Cooks, Ioannis S. Pateras, Lisa M. Jenkins, Keval M. Patel, Ana I. Robles, James Morris, Tim Forshew, Ettore Appella, Vassilis G. Gorgoulis, Curtis C. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7c38fedb00642b095bd023227041cc0
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spelling	oai:doaj.org-article:c7c38fedb00642b095bd023227041cc02021-12-02T17:31:27ZMutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-124610.1038/s41467-018-03224-w2041-1723https://doaj.org/article/c7c38fedb00642b095bd023227041cc02018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03224-whttps://doaj.org/toc/2041-1723p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive macrophages.Tomer CooksIoannis S. PaterasLisa M. JenkinsKeval M. PatelAna I. RoblesJames MorrisTim ForshewEttore AppellaVassilis G. GorgoulisCurtis C. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
description	p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive macrophages.
format	article
author	Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris
author_facet	Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris
author_sort	Tomer Cooks
title	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
title_short	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
title_full	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
title_fullStr	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
title_full_unstemmed	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
title_sort	mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal mir-1246
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c7c38fedb00642b095bd023227041cc0
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Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

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